{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T05:00:32Z","timestamp":1785301232482,"version":"3.55.0"},"reference-count":48,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:00:00Z","timestamp":1784937600000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Macromolecular Bioscience"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>A single component, synthetically tunable amphiphilic copillar[5]arene platform was developed as a modular supramolecular scaffold for therapeutic nano\u2010delivery. Structural variation of the hydrophobic segment, together with PEG functionalization, enables precise control over amphiphilicity, self\u2010assembly, and host\u2010guest behavior, thereby providing a single\u2010component platform that addresses the multicomponent formulation challenges commonly associated with drug delivery systems. Notably, the hydrophobic and electron\u2010rich cavity efficiently assisted in encapsulating a hypoxia\u2010activatable self\u2010immolative linker\u2010based guest, highlighting the potential of this system for encapsulating therapeutically relevant cargos and enabling tumor\u2010selective release. In Vitro studies further demonstrated efficient cellular uptake and negligible toxicity of the blank nanoformulation, validating its suitability as a delivery vehicle. This work establishes copillar[5]arene nano\u2010assemblies as a versatile and synthetically tailorable suprascaffold that combines structural programmability, cargo compatibility, and biological safety, thereby providing a promising platform for precision cancer nanomedicine and advanced drug delivery applications.<\/jats:p>","DOI":"10.1002\/mabi.70216","type":"journal-article","created":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T06:46:07Z","timestamp":1785048367000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Rational Design of Amphiphilic Copillar[5]arene Conjugates for Enhanced Nanodelivery: Synthesis, Nanoparticle Optimization, and In Vitro Biocompatibility"],"prefix":"10.1002","volume":"26","author":[{"given":"Krishna Kanta","family":"Choudhury","sequence":"first","affiliation":[{"name":"Department of Chemical Sciences Indian Institute of Science Education and Research Berhampur  Berhampur Odisha 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