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To address this, the project developed an inflammatory\u2010targeting drug delivery system to mitigate underlying inflammation. The polyvinyl alcohol (PVA) hydrogel, a crosslinked polymer network with excellent water absorption and retention capabilities, was utilized as the drug carrier platform. The polydopamine (PDA) particles were leveraged to effectively eliminate reactive oxygen species and reduce oxidative stress. Furthermore, R\u20107050, a cell\u2010permeable triazoline compound, was encapsulated as a TNF\u2010\u03b1 inhibitor for targeted anti\u2010inflammatory therapy. To enhance therapeutic efficacy, bone marrow mesenchymal stem cells (MSCs) were incorporated into the drug delivery system, which can secrete neurotrophic factors, promote vascular regeneration, and exert superior anti\u2010inflammatory effects. Results have demonstrated that the developed drug delivery system (SC@PDA\/PVA\u2010R7050 Gel) could sustain the release of therapeutic agents in the affected joint area, thereby improving the treatment efficacy. The synergistic integration of the PVA hydrogel, PDA, R\u20107050, and MSCs provides a novel and promising solution for the targeted therapy of osteoarthritis, with significant clinical application potential. 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