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With current treatments, the five\u2010year survival rate for metastatic or recurrent cases remains only 20\u201330%, highlighting the need for new therapeutic approaches and better preclinical models. Our goal is to simulate the osteosarcoma bone microenvironment using melt electrowriting (MEW)\u2010printed polycaprolactone (PCL) scaffolds with optimized calcium phosphate formation. To achieve this, we fabricated PCL scaffolds with distinct MEW micro\u2010architectures, including rectangular, triangular, and hexagonal designs with comparable primary fiber spacing, and investigated two calcium phosphate formation methods: natural cell\u2010generated mineralization and direct calcium phosphate cement coating. Using SaOS\u20102 osteosarcoma cells, we systematically evaluated cell behavior, mineralization dynamics, and scaffold mechanical properties. 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