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This study synthesized biocompatible nanogels via the polymerization of N\u2010vinyl caprolactam and vinyl phosphonic acid. The nanogels containing phosphonic acid groups could tightly bind with Mn\n                    <jats:sup>2+<\/jats:sup>\n                    , which could improve the biosafety by preventing the release of free Mn\n                    <jats:sup>2+<\/jats:sup>\n                    . Meanwhile, the strong ligand effect improved the longitudinal relaxivity of encapsulated Mn\n                    <jats:sup>2+<\/jats:sup>\n                    to 29.8 mM\n                    <jats:sup>\u2212<\/jats:sup>\n                    <jats:sup>1<\/jats:sup>\n                    s\n                    <jats:sup>\u2212<\/jats:sup>\n                    <jats:sup>1<\/jats:sup>\n                    , which was roughly 3.5 times, 10.6 times, and 6.6 times higher than that of manganese chloride (MnCl\n                    <jats:sub>2<\/jats:sub>\n                    ), mangafodipir (MnDPDP) and gadolinium diethylenetriaminepentaacetic acid (Gd\u2010DTPA), respectively. These nanogels exhibited the capability of targeting bone metastases and bone tissues in vivo owing to the phosphonic acid groups. Moreover, these nanogels\u2010based contrast agents prolonged the effective imaging window due to the increased circulation time. They also exhibited a loading capacity for clinical hydrophobic drugs, such as atovaquone (ATO), thereby potentially improving the pharmacokinetics. This work highlights the prospect of poly(vinyl phosphonic acid) based nanogels as multifunctional nanoplatforms for diagnostic and therapeutic applications.\n                  <\/jats:p>","DOI":"10.1002\/mabi.70229","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T10:35:34Z","timestamp":1785926134000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Phosphonic Acid\u2010Enriched Nanogels as High Relaxivity Platforms for Enhanced Magnetic Resonance Imaging and Drug Delivery"],"prefix":"10.1002","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4773-7694","authenticated-orcid":false,"given":"Chanyuan","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Radiology Wuhan Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan China"},{"name":"Department of Radiology Tongji Hospital Tongji Medical College Huazhong 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