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Hydrogels can be crosslinked via dynamic covalent bonds (DCB) in order to done them with the ability to be injected, to self\u2010heal, and to respond to stimuli. In our previous work, reversible thiol\u2010conjugate crosslinks were used in the preparation of dynamic poly(ethylene glycol) (PEG) hydrogels. Because the equilibrium state of these reversible thiol\u2010conjugate bonds can be shifted by temperature, both thermal and photothermal stimuli were used to induce the gel\u2010to\u2010sol transition of these materials to develop an on\u2010demand pulsatile cargo release. However, the dynamic nature of the crosslinks resulted in rapid gel dissolution that prevented their use for long\u2010term drug delivery. In this work, the hydrogels were complemented with stable thiol\u2010maleimide crosslinks to decrease their dissolution rate and prolong their functional lifetime. Data shows that even a small addition of thiol\u2010maleimide crosslinks significantly stabilizes the hydrogels, providing improved control of cargo release initiated by photothermal stimuli but does not cause a notable difference in cargo release at physiological temperature when compared to the hydrogels lacking the stable thiol\u2010maleimide crosslinks.<\/jats:p>","DOI":"10.1002\/mabi.70232","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T02:08:41Z","timestamp":1786932521000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hybrid Dynamic\u2013Covalent PEG Hydrogels With Enhanced Stability for Photothermally Triggered Pulsatile Drug Delivery"],"prefix":"10.1002","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8269-9278","authenticated-orcid":false,"given":"Kushal","family":"Thapa","sequence":"first","affiliation":[{"name":"Materials Science Engineering and 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