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However, none of these studies have used inhibitory effects of probiotics in combination therapies with O\n                    <jats:sub>2<\/jats:sub>\n                    and anticancer drugs for advanced cancer treatment applications. In this study, we report a new probiotic\u2010enriched 3D\u2010printed biomaterial (3D\u2010BioHybrid\u2010DOX\/SPEP) that is capable of O\n                    <jats:sub>2<\/jats:sub>\n                    , probiotic, and acidic pH (pH 6.0) sensitive anticancer drug (Doxorubicin = DOX) co\u2010release. 3D\u2010BioHybrid\u2010DOX\/SPEP shows sustained O\n                    <jats:sub>2<\/jats:sub>\n                    and pH\u2010responsive anticancer drug release over 14 days. The release of short\u2010chain fatty acids, including butyric acid, was detected on days 1 and 7 of incubation, indicating that the O\n                    <jats:sub>2<\/jats:sub>\n                    delivery component of the system supports probiotic viability while mitigating the toxic effects of DOX. The CFU results show that the 3D\u2010BioHybrid\u2010DOX\/SPEP supports probiotic viability at 1 and 7 days of incubation. In vitro cell experiments indicate that the healthy cell viability is ca. 2 times higher than cancer cells after 1 and 7 days of incubation at hypoxia conditions in 3D\u2010BioHybrid\u2010DOX\/SPEP due to the co\u2010administration of O\n                    <jats:sub>2<\/jats:sub>\n                    , DOX, and probiotics.\n                  <\/jats:p>","DOI":"10.1002\/mabi.70233","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T19:02:21Z","timestamp":1789066941000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Living Biohybrid Hydrogels for Co\u2010Delivery of Oxygen, Anti\u2010Cancer Drugs, and Probiotics: Effects on Cancer and Healthy Cell Viability"],"prefix":"10.1002","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4800-2552","authenticated-orcid":false,"given":"Ulvi","family":"S\u00fcleymanzade","sequence":"first","affiliation":[{"name":"Department of 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