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Unlike conventional hydrogels, cryogels are fabricated through cryogelation\u2014a sub\u2010zero polymerization process that generates interconnected macropores through ice crystal templating\u2014endowing them with sponge\u2010like elasticity and the ability to withstand extreme compression and recover their original architecture upon injection. Over the past decade, injectable cryogels have evolved from simple porous scaffolds to sophisticated multifunctional platforms incorporating nanocomposites, bioactive molecules, and stimuli\u2010responsive elements for applications spanning bone and cartilage regeneration, stem cell delivery, cancer immunotherapy, and hemostatic wound healing. This review provides a comprehensive and critical analysis of recent advances in shape\u2010memory injectable cryogels, organized around five interconnected themes: (i) the physicochemical mechanisms governing shape\u2010memory behavior and material design strategies, (ii) emerging fabrication approaches including three\u2010dimensional printing\u2013cryogelation hybrids and nanocomposite reinforcement, (iii) cryogel\u2010mediated stem cell delivery and tissue regeneration, (iv) immunomodulatory and vaccine platforms, and (v) hemostatic and wound\u2010healing applications. We critically evaluate how macro\u2010architectural features, mechanical tunability, and biochemical functionalization collectively dictate biological outcomes, and identify key challenges\u2014including scalability, sterilization, regulatory pathways, and clinical translation\u2014that must be addressed to realize the full therapeutic potential of injectable cryogels.<\/jats:p>","DOI":"10.1002\/mabi.70241","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T03:48:58Z","timestamp":1786592938000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Shape\u2010Memory Injectable Cryogels: From Minimally Invasive Delivery to Multifunctional Tissue Regeneration"],"prefix":"10.1002","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-6483-1705","authenticated-orcid":false,"given":"Yeajin","family":"Song","sequence":"first","affiliation":[{"name":"Department of Biomedical 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