{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:17:14Z","timestamp":1787840234340,"version":"build-2784847793"},"reference-count":53,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51103071"],"award-info":[{"award-number":["51103071"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Macromolecular Bioscience"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Hydrogel\u2010based dressings are widely used in wound healing. Herein, we report a polyacrylic acid (PAA)\/polyvinyl alcohol (PVA) composite hydrogel fabricated via self\u2010catalyzed free radical polymerization, with borax serving as the reinforcing phase. Meanwhile, metal\u2010ligand coordination bonding between tannic acid (TA) and Fe\n                    <jats:sup>3<\/jats:sup>\n                    <jats:sup>+<\/jats:sup>\n                    further elevates the crosslinking density of the hydrogel network. Magnetic chitosan microspheres (MCMs) were synthesized by emulsion cross\u2010linking and loaded with two antibacterial agents, namely tetracycline hydrochloride (TH) and berberine hydrochloride (Bbh). The incorporation of MCMs into the hydrogel matrix resulted in the development of a multifunctional composite hydrogel suitable for wound dressing applications. Results demonstrated that the composite hydrogel containing a specific concentration of 4\u2030 (w\/v) borax and 20 mg\/mL MCMs exhibited superior performance, including enhanced mechanical strength, improved responsiveness, sustained drug release, and potent antibacterial efficacy. The core novelty of this work lies in the synergistic integration of borax\u2010based mechanical reinforcement, MCM\u2010mediated dual drug loading and sustained release, and the self\u2010catalyzed polymerization system. This innovative structural and functional collaboration effectively optimizes the mechanical stability of the hydrogel dressing and achieves synergistic antibacterial and intelligent responsive therapeutic performances, providing a reliable and high\u2010efficiency candidate for advanced wound care and next\u2010generation wound dressing applications.\n                  <\/jats:p>","DOI":"10.1002\/mabi.70242","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T03:50:15Z","timestamp":1786593015000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Microsphere\u2010Loaded and Borax\u2010Reinforced Polyacrylic Acid (PAA)\/Polyvinyl Alcohol (PVA) Hydrogels Incorporating Tannic Acid: Ultra\u2010High Toughness and Antibacterial Properties for Artificial Intelligence 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