{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:57:27Z","timestamp":1790618247882,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Macromolecular Bioscience"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Alveolar ridge deficiency remains a significant clinical challenge in dental implantology, often necessitating bone augmentation procedures. While autogenous bone grafting is considered the gold standard, its limitations, including donor site complications and limited availability, have prompted the development of alternative bone graft materials. In this study, we fabricated a novel polycaprolactone (PCL)\/\u03b2\u2010tricalcium phosphate (\u03b2\u2010TCP)@zinc oxide (ZnO) composite scaffold via direct ink writing (DIW) three\u2010dimensional (3D) printing. The scaffold integrates a biomimetic porous architecture with a controlled ion\u2010release strategy to enhance osteogenic performance. The characterization of the material confirmed excellent chemical stability, hydrophilicity, and tunable degradation behavior. The incorporation of ZnO facilitated the sustained release of bioactive ions (Ca\n                    <jats:sup>2+<\/jats:sup>\n                    , PO\n                    <jats:sub>4<\/jats:sub>\n                    <jats:sup>3\u2212<\/jats:sup>\n                    , and Zn\n                    <jats:sup>2+<\/jats:sup>\n                    ), significantly improving the scaffold's bioactivity. In vitro assessments revealed that the scaffold with 2% ZnO (PTZ\u20102) exhibited optimal cytocompatibility and osteogenic differentiation capacity, promoting alkaline phosphatase activity and mineralized nodule formation in MC3T3\u2010E1 cells. In a rat cranial defect model, the PTZ\u20102 scaffold achieved approximately 95% new bone area after 12 weeks. Histological analysis further confirmed the presence of continuous, highly mineralized bone matrix with excellent osseointegration capability. These findings collectively indicate that the 3D\u2010printed PCL\/\u03b2\u2010TCP@ZnO composite scaffold has great potential for clinical translation in bone defect regeneration.\n                  <\/jats:p>","DOI":"10.1002\/mabi.70245","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T15:25:51Z","timestamp":1788362751000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Functionalized 3D\u2010Printed PCL\/\u03b2\u2010TCP Scaffolds with ZnO for Enhanced Bone Healing"],"prefix":"10.1002","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7187-3519","authenticated-orcid":false,"given":"Ayijiamila","family":"Mohetaer","sequence":"first","affiliation":[{"name":"School\/Hospital of Stomatology Lanzhou University  Lanzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Rong","sequence":"additional","affiliation":[{"name":"School\/Hospital of Stomatology Lanzhou University  Lanzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4567-5120","authenticated-orcid":false,"given":"Zhang","family":"Jing","sequence":"additional","affiliation":[{"name":"School\/Hospital of Stomatology Lanzhou University  Lanzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Yuxin","sequence":"additional","affiliation":[{"name":"School\/Hospital of Stomatology Lanzhou University  Lanzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan","family":"Xiaofei","sequence":"additional","affiliation":[{"name":"School\/Hospital of Stomatology Lanzhou University  Lanzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Qian","sequence":"additional","affiliation":[{"name":"School\/Hospital of Stomatology Lanzhou University  Lanzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma","family":"Chunquan","sequence":"additional","affiliation":[{"name":"School\/Hospital of Stomatology Lanzhou University  Lanzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Bin","sequence":"additional","affiliation":[{"name":"School\/Hospital of Stomatology Lanzhou University  Lanzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Fuxiang","sequence":"additional","affiliation":[{"name":"School\/Hospital of Stomatology Lanzhou University  Lanzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100501.2011.02375.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.14177"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8060537"},{"issue":"2","key":"e_1_2_8_5_1","first-page":"S203","article-title":"Autogenous Bone Harvesting and Grafting in Advanced Jaw Resorption: Morbidity, Resorption and Implant Survival","volume":"7","author":"Nkenke E.","year":"2014","journal-title":"European Journal of Oral Implantology"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOT.0000000000001420"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma16114117"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40824\u2010019\u20100157\u2010y"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13936"},{"issue":"2","key":"e_1_2_8_10_1","first-page":"152","article-title":"A New Concept in Maxillary Implant Surgery: the Osteotome Technique","volume":"15","author":"Summers R. 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