{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:57:29Z","timestamp":1790618249498,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Macromolecular Bioscience"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Acute full\u2011thickness skin wounds represent a significant clinical challenge due to tissue loss, risk of bacterial contamination, and the need for rapid and effective regeneration. Injectable thermosensitive hydrogels incorporating antibacterial nanomaterials represent a promising strategy for advanced wound care. In this study, a multifunctional hydrogel composed of Graphene oxide (GO), branched polyethyleneimine (BPEI), and silver nanoparticles (AgNPs) dispersed in Pluronic F127 was developed and evaluated for wound healing applications. The GO\u2010BPEI\u2010AgNP nanocomposite was synthesized via amidation and microwave\u2010assisted methods and characterized using DLS, UV\u2013vis, FTIR, XRD, and SEM\u2013EDX analyses. Biocompatibility was assessed in HaCaT keratinocytes using the Alamar Blue assay, while scratch assays and antibacterial activity against. In vivo wound healing efficacy and histopathological changes were evaluated in a rat full\u2010thickness skin wound model, together with qRT\u2010PCR analysis of wound\u2010healing\u2010related genes. The hydrogel exhibited favorable injectability, nanoscale morphology, and high biocompatibility (IC\n                    <jats:sub>50<\/jats:sub>\n                    : 246.7\u00a0\u00b5g\/mL). It significantly enhanced keratinocyte migration and demonstrated antibacterial activity. In vivo findings revealed accelerated wound closure, enhanced epidermal regeneration, and modulation of PDGFA, VEGFC, COL1A1, TIMP1, and MMP9 expression. Collectively, the GO\u2011BPEI\u2011AgNP hydrogel shows strong potential as an injectable antibacterial biomaterial for acute full\u2011thickness wound repair, with potential relevance to infection\u2011associated wound environments.\n                  <\/jats:p>","DOI":"10.1002\/mabi.70260","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T18:27:38Z","timestamp":1789669658000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fabrication and Application of Injectable Bpei\/Graphene Oxide\/Silver Nanoparticle Hydrogel for Wound Healing"],"prefix":"10.1002","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0881-9793","authenticated-orcid":false,"given":"Kemal","family":"Bas","sequence":"first","affiliation":[{"name":"Chemical Biology Radiology and Nuclear Defense Institute of Health Sciences Selcuk University  Konya T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4449-6103","authenticated-orcid":false,"given":"Serdar","family":"Karakurt","sequence":"additional","affiliation":[{"name":"Chemical Biology Radiology and Nuclear Defense Institute of Health Sciences Selcuk University  Konya T\u00fcrkiye"},{"name":"Faculty of Science Department of Biochemistry Selcuk University  Konya T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.33631\/duzcesbed.562187"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.31832\/smj.824924"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0TB01074J"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2020.127589"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201801471"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2019.01.028"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.35544"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.7b16235"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioadv.2022.212737"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma12132176"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reactfunctpolym.2023.105592"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15010257"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S400798"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/smmd.70017"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jece.2021.105843"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40089\u2010020\u201000305\u2010x"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.inoche.2020.108115"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2017.06.018"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2018.10.120"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00775\u2010007\u20100208\u2010z"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbon.2013.08.038"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6TB01647B"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiec.2013.11.061"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b11411"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2019.09.143"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.6b06052"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.materresbull.2023.112352"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtcomm.2022.103663"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871520616666151111115809"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/s120912347"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.3906\/biy\u20102002\u201030"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rineng.2022.100742"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1101\/pdb.prot5439"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcs9030133"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reth.2025.04.020"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.145879"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010025\u201093310\u2010z"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10565\u2010025\u201010062\u20102"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2013.0517"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering9050191"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S218120"}],"container-title":["Macromolecular Bioscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mabi.70260","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mabi.70260","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mabi.70260","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:08:42Z","timestamp":1790615322000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mabi.70260"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":41,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/mabi.70260"],"URL":"https:\/\/doi.org\/10.1002\/mabi.70260","archive":["Portico"],"relation":{},"ISSN":["1616-5187","1616-5195"],"issn-type":[{"value":"1616-5187","type":"print"},{"value":"1616-5195","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2026-05-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70260"}}