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Numerous studies have suggested that ferroptosis serves as a bona fide target for antitumor therapies. However, therapeutic efficacy and tumor\u2010targeting capacity still need to be improved, and the underlying mechanisms need to be studied and illustrated. In this study, a nanoformulation of folate\u2010acid\u2010decorated Fe\u2010loaded heparin nanoparticles was rationally designed with the intention of facilitating tumor accumulation for antitumor therapy, with efficient ferroptosis efficacy. The results of both in vitro and in vivo experiments indicated that the nanomedication used in this study could provide an effective antitumor system with efficient ferroptosis capacity and satisfactory biosafety.<\/jats:p>","DOI":"10.1002\/mabi.70261","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T18:22:28Z","timestamp":1789669348000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Heparin\u2010Based Nanoparticles for Targeted Anti\u2010Tumor Therapy by Efficient Ferroptosis"],"prefix":"10.1002","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8278-5224","authenticated-orcid":false,"given":"Jianquan","family":"Wang","sequence":"first","affiliation":[{"name":"College of Materials Engineering Jinling Institute of Technology  Nanjing 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