{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:57:29Z","timestamp":1790618249524,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Macromolecular Bioscience"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Fluorescent organic nanoparticles (FONPs) with intrinsic fluorescence and self\u2010assembled vesicles (VES) are receiving widespread interest in biomedicine. Both FONPs and VES have individual drawbacks like cytotoxicity of FONPs while VES gets eliminated through reticuloendothelial system impeding their applications. Development of nanoconjugates through amalgamation of individual nanocarrier with complementing features would find greater significance by overcoming individual hurdles. Herein, we report design and synthesis of FONP\u2010VES nanoconjugate by combining naphthalimide\u2010based pH\u2010responsive hydrazone moiety containing FONP (\n                    <jats:bold>NIHYDH<\/jats:bold>\n                    ) and cholesterol\u2010based vesicle (\n                    <jats:bold>CBAV<\/jats:bold>\n                    ) via electrostatic interaction. FONP, VES and FONP\u2010VES conjugate were characterized by spectroscopy and microscopy. Orange emitting\n                    <jats:bold>NIHYDH\u2010CBAV<\/jats:bold>\n                    nanoconjugate was utilised in bioimaging and as delivery vehicle which demonstrated targeted transport of tamoxifen (TAM) to (ER+) MCF7 cells through pH\u2010responsive dissipation of nanoconjugate owing to cleavage of hydrazone bond under acidic pH gradient. TAM has demonstrated clinical drug resistance along with limited bioavailability. Upon encapsulation within nanoconjugate,\n                    <jats:bold>NIHYDH\u2010CBAV<\/jats:bold>\n                    \u2010TAM offered \u223c2.8\u2010fold higher cytotoxicity toward MCF7 cells compared to normal NIH3T3 cells alongside demonstrating \u223c2.1\u2010fold reduction in the size of MCF7 3D tumour spheroids. TAM loaded nanoconjugate was \u223c2.2\u20103.4\u2010fold more cytotoxic than TAM loaded individual nanocarrier. Cytotoxicity of\n                    <jats:bold>NIHYDH\u2010CBAV<\/jats:bold>\n                    \u2010TAM got enhanced due to increased intracellular oxidative stress that triggered p53 upregulated cell apoptotic pathway.\n                  <\/jats:p>","DOI":"10.1002\/mabi.70264","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T07:18:19Z","timestamp":1789975099000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tamoxifen Loaded Conjugate of Self\u2010Assembled Fluorescent Organic Nanoparticle and Vesicle for p53\u2010Activated Breast Cancer Therapy"],"prefix":"10.1002","volume":"26","author":[{"given":"Debolina","family":"Basu","sequence":"first","affiliation":[{"name":"School of Biological Sciences Indian Association for the Cultivation of Science  Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathakoli","family":"Roy","sequence":"additional","affiliation":[{"name":"School of Biological Sciences Indian Association for the Cultivation of Science  Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0203-8446","authenticated-orcid":false,"given":"Prasanta Kumar","family":"Das","sequence":"additional","affiliation":[{"name":"School of Biological Sciences Indian Association for the Cultivation of Science  Kolkata 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