{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:49:12Z","timestamp":1790383752665,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,10,6]],"date-time":"2016-10-06T00:00:00Z","timestamp":1475712000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["EB001046"],"award-info":[{"award-number":["EB001046"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Macro Materials &amp;amp; Eng"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:p>The effects of ethylene oxide (EO), vaporized hydrogen peroxide (VHP), gamma (\u03b3) radiation, and electron\u2010beam (E\u2010beam) on the physiochemical and morphological properties of medical device polymers are investigated. Polymers with ether, carbonate, carboxylic acid, amide and ester functionalities are selected from a family of poly(ethylene glycol) (PEG) containing tyrosine\u2010derived polycarbonates (TyrPCs) to include slow, medium, fast, and ultra\u2010fast degrading polymers. Poly(lactic acid) (PLA) is used for comparison. Molecular weight (<jats:italic>M<\/jats:italic><jats:sub>w<\/jats:sub>) of all tested polymers decreases upon gamma and E\u2010beam, and this effect becomes more pronounced at higher PEG content. Gamma sterilization increases the glass transition temperature of polymers with high PEG content. EO esterifies the carboxylic acid groups in desaminotyrosol\u2010tyrosine (DT) and causes significant degradation. VHP causes hydroxylation of the phenyl ring, and hydrolytic degradation. This study signifies the importance of the chemical composition when selecting a sterilization method, and provides suggested conditions for each of the sterilization methods.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/mame201600133-abs-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p>","DOI":"10.1002\/mame.201600133","type":"journal-article","created":{"date-parts":[[2016,7,11]],"date-time":"2016-07-11T12:02:11Z","timestamp":1468238531000},"page":"1211-1224","source":"Crossref","is-referenced-by-count":35,"title":["Effects of Terminal Sterilization on PEG\u2010Based Bioresorbable Polymers Used in Biomedical Applications"],"prefix":"10.1002","volume":"301","author":[{"given":"Divya","family":"Bhatnagar","sequence":"first","affiliation":[{"name":"NJ Centre for Biomaterials Rutgers\u2010The State University of New Jersey  145 Bevier Road Piscataway NJ 08854 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koustubh","family":"Dube","sequence":"additional","affiliation":[{"name":"NJ Centre for Biomaterials Rutgers\u2010The State University of New Jersey  145 Bevier Road Piscataway NJ 08854 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod B.","family":"Damodaran","sequence":"additional","affiliation":[{"name":"NJ Centre for Biomaterials Rutgers\u2010The State University of New Jersey  145 Bevier Road Piscataway NJ 08854 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganesan","family":"Subramanian","sequence":"additional","affiliation":[{"name":"NJ Centre for Biomaterials Rutgers\u2010The State University of New Jersey  145 Bevier Road Piscataway NJ 08854 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Aston","sequence":"additional","affiliation":[{"name":"Johnson &amp; Johnson Sterility Assurance  930 US 202 Raritan NJ 08669 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick","family":"Halperin","sequence":"additional","affiliation":[{"name":"Johnson &amp; Johnson Sterility Assurance  930 US 202 Raritan NJ 08669 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiyu","family":"Mao","sequence":"additional","affiliation":[{"name":"Johnson &amp; Johnson Sterility Assurance  930 US 202 Raritan NJ 08669 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt","family":"Pricer","sequence":"additional","affiliation":[{"name":"Johnson &amp; Johnson Sterility Assurance  930 US 202 Raritan NJ 08669 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. 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