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UV irradiation of the Nvoc\u2010FF hydrogel encapsulating insulin\u2010fluorescein isothiocyanate (insulin\u2010FITC) results in the cleavage of Nvoc\u2010FF peptide to produce unmasked FF, thereby facilitating the degradation of the hydrogel and the release of insulin\u2010FITC. This release is in linear correlation to the irradiation time. In the present study, a first insight into this rigid, fibrous, light\u2010responsive hydrogel is provided, allowing the fabrication of a novel drug delivery system for controlled release of large molecules.<\/jats:p>","DOI":"10.1002\/marc.201800588","type":"journal-article","created":{"date-parts":[[2018,10,2]],"date-time":"2018-10-02T06:08:30Z","timestamp":1538460510000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":113,"title":["UV Light\u2013Responsive Peptide\u2010Based Supramolecular Hydrogel for Controlled Drug Delivery"],"prefix":"10.1002","volume":"39","author":[{"given":"Michal E.","family":"Roth\u2010Konforti","sequence":"first","affiliation":[{"name":"School of Chemistry, Faculty of Exact Sciences Tel Aviv University  Tel Aviv 69978 Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0835-7832","authenticated-orcid":false,"given":"Michela","family":"Comune","sequence":"additional","affiliation":[{"name":"Department of Oral Biology The Goldschleger School of Dental Medicine Sackler Faculty of Medicine Tel Aviv University  Tel Aviv 69978 Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Halperin\u2010Sternfeld","sequence":"additional","affiliation":[{"name":"Department of Oral Biology The Goldschleger School of Dental Medicine Sackler Faculty of Medicine Tel Aviv University  Tel Aviv 69978 Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irena","family":"Grigoriants","sequence":"additional","affiliation":[{"name":"Department of Oral Biology The Goldschleger School of Dental Medicine Sackler Faculty of Medicine Tel Aviv University  Tel Aviv 69978 Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doron","family":"Shabat","sequence":"additional","affiliation":[{"name":"School of Chemistry, Faculty of Exact Sciences Tel Aviv University  Tel Aviv 69978 Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3433-0625","authenticated-orcid":false,"given":"Lihi","family":"Adler\u2010Abramovich","sequence":"additional","affiliation":[{"name":"Department of Oral Biology The Goldschleger School of Dental Medicine Sackler Faculty of Medicine Tel Aviv University  Tel Aviv 69978 Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10]]},"reference":[{"key":"e_1_2_4_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymer.2008.01.027"},{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemmater.5b02839"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201500402"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2018.03.018"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2013.07.006"},{"key":"e_1_2_4_6_1","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1002\/btm2.10041","volume":"1","author":"Yi L.","year":"2016","journal-title":"Bioeng. 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