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Rapid Commun."],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Additive manufacturing via melt electrowriting (MEW) can create ordered microfiber scaffolds relevant for bone tissue engineering; however, there remain limitations in the adoption of new printing materials, especially in MEW of biomaterials. For example, while promising composite formulations of polycaprolactone with strontium\u2010substituted bioactive glass have been processed into large or disordered fibres, from what is known, biologically\u2010relevant concentrations (&gt;10 wt%) have never been printed into ordered microfibers using MEW. In this study, rheological characterization is used in combination with a predictive mathematical model to optimize biomaterial formulations and MEW conditions required to extrude various PCL and PCL\/SrBG biomaterials to create ordered scaffolds. Previously, MEW printing of PCL\/SrBG composites with 33 wt% glass required unachievable extrusion pressures. The composite formulation is modified using an evaporable solvent to reduce viscosity 100\u2010fold to fall within the predicted MEW pressure, temperature, and voltage tolerances, which enabled printing. This study reports the first fabrication of reproducible, ordered high\u2010content bioactive glass microfiber scaffolds by applying predictive modeling.<\/jats:p>","DOI":"10.1002\/marc.201900019","type":"journal-article","created":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T11:49:52Z","timestamp":1554119392000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Rheological Characterization of Biomaterials Directs Additive Manufacturing of Strontium\u2010Substituted Bioactive Glass\/Polycaprolactone Microfibers"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3052-4764","authenticated-orcid":false,"given":"Naomi C.","family":"Paxton","sequence":"first","affiliation":[{"name":"Institute of Health and Biomedical Innovation (IHBI) Queensland University of Technology (QUT)  60 Musk Ave Kelvin Grove QLD 4059 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