{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T04:57:49Z","timestamp":1778907469812,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2019,7,12]],"date-time":"2019-07-12T00:00:00Z","timestamp":1562889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB1176"],"award-info":[{"award-number":["SFB1176"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Macromol. Rapid Commun."],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Online chemically sensitive detectors for size exclusion chromatography (SEC) through coupled setups based on infrared (IR) (or NMR) spectrometers present new possibilities through unprecedented levels of polymer detail with respect to molecular weight and chemical composition. Herein, a new external cavity quantum cascade laser (EC\u2010QCL) mid\u2010IR spectrometer as a chemically sensitive online detector for SEC is custom\u2010designed, built, and tested. This unique spectrometer features multiple broadly tunable EC\u2010QCL sources, which can be operated in continuous wave and pulsed mode, accompanied with balanced liquid nitrogen cooled mercury cadmium telluride (MCT) detectors and a new custom\u2010built transmission flow cell. Automated data analysis is done with a self\u2010written MATLAB code. The limit of detection (LOD) is measured online, coupled with SEC chromatography, where on average, one carbonyl functionality in 530\u2009000 g mol<jats:sup>\u22121<\/jats:sup> at chromatographic conditions for SEC could be detected. It is possible to detect 0.46 \u00b5g (LOD) PMMA, which is approximately a factor of 30 lower than that reported for SEC\u2010Fourier transform infrared.<\/jats:p>","DOI":"10.1002\/marc.201900228","type":"journal-article","created":{"date-parts":[[2019,7,12]],"date-time":"2019-07-12T13:19:31Z","timestamp":1562937571000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["A New Quantum Cascade IR\u2010Laser Online Detector: Chemical\u2010Sensitive Size\u2010Exclusion Chromatography Measurement at Unprecedented Low Levels"],"prefix":"10.1002","volume":"40","author":[{"given":"Jennifer M.","family":"K\u00fcbel","sequence":"first","affiliation":[{"name":"Institute of Chemical Technology and Polymer Chemistry Karlsruhe Institute of Technology (KIT)  Engesserstra\u00dfe 18 76131 Karlsruhe Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0930-1291","authenticated-orcid":false,"given":"Carlo","family":"Botha","sequence":"additional","affiliation":[{"name":"Institute of Chemical Technology and Polymer Chemistry Karlsruhe Institute of Technology (KIT)  Engesserstra\u00dfe 18 76131 Karlsruhe Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Bucka","sequence":"additional","affiliation":[{"name":"Institute of Chemical Technology and Polymer Chemistry Karlsruhe Institute of Technology (KIT)  Engesserstra\u00dfe 18 76131 Karlsruhe Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"H\u00f6pfner","sequence":"additional","affiliation":[{"name":"Institute of Chemical Technology and Polymer Chemistry Karlsruhe Institute of Technology (KIT)  Engesserstra\u00dfe 18 76131 Karlsruhe Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Zimmermann","sequence":"additional","affiliation":[{"name":"neoplas control GmbH  Walther\u2010Rathenau\u2010Stra\u00dfe 49a 17489 Greifswald Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Godejohann","sequence":"additional","affiliation":[{"name":"MG Optical Solutions GmbH  Industriestra\u00dfe 23 86919 Utting\/Ammersee Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1465-9861","authenticated-orcid":false,"given":"Manfred","family":"Wilhelm","sequence":"additional","affiliation":[{"name":"Institute of Chemical Technology and Polymer Chemistry Karlsruhe Institute of Technology (KIT)  Engesserstra\u00dfe 18 76131 Karlsruhe Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,7,12]]},"reference":[{"key":"e_1_2_4_1_1","doi-asserted-by":"publisher","DOI":"10.1093\/acprof:oso\/9780198528241.001.0001"},{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00340-008-3047-x"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cplett.2009.12.073"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1117\/12.2082794"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-016-9923-z"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1117\/12.2183952"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/photonics3020031"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7CS00403F"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1366\/14-00001"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1364\/AO.56.000E23"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.1931233"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/marc.201200403"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4PY01043D"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/marc.201700307"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3an01546g"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.5b01738"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.8b01632"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00340-012-5080-z"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.progpolymsci.2013.10.001"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/macp.201200092"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/marc.201700766"},{"key":"e_1_2_4_22_1","author":"Botha C.","year":"2019","journal-title":"Polym. Chem."},{"key":"e_1_2_4_23_1","first-page":"89931","volume":"8993","author":"Brandstetter M.","year":"2014","journal-title":"Proc. SPIE"},{"key":"e_1_2_4_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac950580w"},{"key":"e_1_2_4_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-2670(98)00798-3"}],"container-title":["Macromolecular Rapid Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmarc.201900228","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/marc.201900228","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/marc.201900228","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/marc.201900228","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T12:10:14Z","timestamp":1694261414000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/marc.201900228"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,12]]},"references-count":25,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1002\/marc.201900228"],"URL":"https:\/\/doi.org\/10.1002\/marc.201900228","archive":["Portico"],"relation":{},"ISSN":["1022-1336","1521-3927"],"issn-type":[{"value":"1022-1336","type":"print"},{"value":"1521-3927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,12]]},"assertion":[{"value":"2019-05-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"1900228"}}