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Rapid Commun."],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Transplantation of microencapsulated islet cells holds great potential for the treatment of type 1 diabetes mellitus. However, its clinical translation is hampered by the peri\u2010transplantation loss of islet viability and functionality in the microcapsules. In this work, a novel islet cells biomimetic microencapsulant material that is based on the interpenetrating networks of alginate and extracellular matrix (ECM) hydrogel composite (AEC) is presented. The ECM component is derived from human lipoaspirate. In situ encapsulation of pancreatic \u03b2 islet cells (MIN6 \u03b2\u2010cells) can be achieved via ionotropic gelation of the alginate matrix and thermal\u2010induced gelation of the pepsin\u2010solubilized ECM pre\u2010gel. Due to the enhanced cell\u2013matrix interaction, islets encapsulated within the AEC microcapsules (\u2248640\u00a0\u00b5m) display sevenfold increase in cell growth over 1 week of culture and characteristic glucose\u2010stimulated insulin response in vitro. The results show that the AEC microcapsule is a potent platform to bioaugment the performance of islet cells.<\/jats:p>","DOI":"10.1002\/marc.202000275","type":"journal-article","created":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T19:44:27Z","timestamp":1598557467000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Interpenetrating Network of Alginate\u2013Human Adipose Extracellular Matrix Hydrogel for Islet Cells Encapsulation"],"prefix":"10.1002","volume":"41","author":[{"given":"Jun Kit","family":"Wang","sequence":"first","affiliation":[{"name":"School of Materials Science and Engineering Nanyang Technological University Singapore  N4.1, 50 Nanyang Avenue Singapore 639798 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole Mein Ji","family":"Cheam","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering Nanyang Technological University 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