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Rapid Commun."],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study assesses the use of immobilized lipase catalyst N435 during reactive extrusion (REX) versus magnetically stirred bulk and solution reaction conditions for the copolymerization of \u03b5\u2010caprolactone with\u00a0\u03c9\u2010pentadecalactone (CL\/PDL 1:1 molar). N435\u2010catalyzed REX for reaction times from 1 to 3 h results in total %\u2010monomer conversion, <jats:italic>M<jats:sub>n<\/jats:sub><\/jats:italic>,\u00a0and <jats:italic>\u0110<\/jats:italic> values increase from 92.7% to 98.8%, 36.1 to 51.3\u00a0kDa, and 1.85 to 1.96, respectively. Diad fraction analysis by quantitative\u00a0<jats:sup>13<\/jats:sup>C NMR reveals that, after just 1 h, rapid N435\u2010catalyzed transesterification reactions occur that give\u00a0random copolyesters. In contrast, for bulk polymerization with magnetic stirring in round bottom flasks, reaction times from 1 to 3 h result in the following: <jats:italic>M<jats:sub>n<\/jats:sub><\/jats:italic>\u00a0increases from 12.4 to 25.6\u00a0kDa, <jats:italic>\u0110<\/jats:italic> decreases from 2.98 to 1.87, and the randomness index increases from 0.74 and 0.86 as PDL*\u2013PDL diads are dominant. These results highlight that REX avoids problems associated with internal batch mixing that are encountered in bulk polymerizations. In sharp contrast to a previous study of 1:1 molar PDL\/\u03b4\u2010valerolactone (VL) copolymerizations by N435\u2010catalyzed REX, VL %\u2010conversion increases to just 40.1% in 1 h whereas CL reaches 94.7%.<\/jats:p>","DOI":"10.1002\/marc.202000417","type":"journal-article","created":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T06:04:04Z","timestamp":1602569044000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Lipase\u2010Catalyzed Reactive Extrusion: Copolymerization of \u03b5\u2010Caprolactone and \u03c9\u2010Pentadecalactone"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2832-757X","authenticated-orcid":false,"given":"Changcun","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Chemo\/Biosensing and Chemometrics College of Chemistry and Chemical Engineering Institute of Polymer Science and Engineering Hunan University  Changsha 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