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Such polycations are demonstrated to be promising nonviral gene delivery vectors with high transfection efficiency (up to 3.5\u2010fold of PEI25k) and low toxicity with multiple functionalities: 1) efficient gene condensation by tertiary amine groups; 2) reactive oxygen species scavenging by thioether groups; and 3) positive charge shielding by hydroxyl groups. Both the thioether and hydroxyl groups are contributed to reduce the cytotoxicity of the polycations by tuning the oxidative stress and preventing the undesired serum binding. The optimized polycations can achieve high transfection efficiency under the serum conditions, indicating the great potential as a nonviral gene delivery vector candidate for clinical application.\n                  <\/jats:p>","DOI":"10.1002\/marc.202000464","type":"journal-article","created":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T01:38:18Z","timestamp":1602639498000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Multicomponent Polymerization toward Cationic Polymers for Efficient Gene Delivery"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8808-5154","authenticated-orcid":false,"given":"Nan","family":"Zheng","sequence":"first","affiliation":[{"name":"State Key Laboratory of Fine Chemicals School of Chemical Engineering Dalian University of Technology  Dalian 116024 P. R. 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