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Rapid Commun."],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In recent years, transdermal drug delivery based on microneedles (MNs) technology has\u00a0received extensive attention, which offers a safer and painless alternative to hypodermic needle injections. They can pierce the stratum corneum and deliver drugs to the epidermis and dermis\u2010structures of skin, showing prominent properties such as minimally invasiveness, bypassing first\u2010pass metabolism, and can be self\u2010administered. A range of materials has been used to fabricate MNs, such as silicon, metal, glass, and polymers. Among them, polymer MNs have gained increasing attention from pharmaceutical and cosmetic companies as one of the promising drug delivery methods. MN products have recently become available on the market, and some of them are under evaluation for efficacy and safety.\u00a0This paper focuses on the current state of polymer MNs in drug transdermal delivery. The materials and methods for the fabrication of polymer MNs and their drug administration are described. The recent progress of polymer MNs for treatment of cancer, vaccine delivery, blood glucose regulation, androgenetic alopecia, obesity, tissue healing, myocardial infarction, and gout are reviewed. The challenges of MNs technology are summarized and the future development trend of MNs is also prospected.<\/jats:p>","DOI":"10.1002\/marc.202200037","type":"journal-article","created":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T18:23:29Z","timestamp":1647282209000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Recent Advances in Polymer Microneedles for Drug Transdermal Delivery: Design Strategies and Applications"],"prefix":"10.1002","volume":"43","author":[{"given":"Rui","family":"Wang","sequence":"first","affiliation":[{"name":"School of Materials Science and Engineering Zhejiang Sci\u2010Tech University  Hangzhou 310018 China"},{"name":"International Scientific and Technological Cooperation Base of Intelligent Biomaterials and Functional Fibers Zhejiang Sci\u2010Tech University  Hangzhou 310018 China"},{"name":"Zhejiang\u2010Mauritius Joint Research Center for Biomaterials and Tissue Engineering Zhejiang Sci\u2010Tech University  Hangzhou 310018 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3666-8216","authenticated-orcid":false,"given":"Guohua","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering Zhejiang Sci\u2010Tech University  Hangzhou 310018 China"},{"name":"International Scientific and Technological Cooperation Base of Intelligent Biomaterials and Functional Fibers Zhejiang Sci\u2010Tech University  Hangzhou 310018 China"},{"name":"Zhejiang\u2010Mauritius Joint Research Center for Biomaterials and Tissue Engineering Zhejiang Sci\u2010Tech University  Hangzhou 310018 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uladzislau E.","family":"Aharodnikau","sequence":"additional","affiliation":[{"name":"Research Institute for Physical Chemical Problems Belarusian State University  Minsk 220030 Belarus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaydar","family":"Yunusov","sequence":"additional","affiliation":[{"name":"Institute of Polymer Chemistry and Physics Uzbekistan Academy of Sciences  Tashkent 100128 Uzbekistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfang","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Life Sciences and Medicine Zhejiang Sci\u2010Tech University  Hangzhou Zhejiang 310018 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianqi","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering Zhejiang Sci\u2010Tech University  Hangzhou 310018 China"},{"name":"International Scientific and Technological Cooperation Base of Intelligent Biomaterials and Functional Fibers Zhejiang Sci\u2010Tech University  Hangzhou 310018 China"},{"name":"Zhejiang\u2010Mauritius Joint Research Center for Biomaterials and Tissue Engineering Zhejiang Sci\u2010Tech University  Hangzhou 310018 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey O.","family":"Solomevich","sequence":"additional","affiliation":[{"name":"Research Institute for Physical Chemical Problems Belarusian State University  Minsk 220030 Belarus"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,23]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mattod.2021.03.012"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics11030129"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2020.105280"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.01.019"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym13162815"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2017.11.007"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2021.102477"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425247.2016.1232247"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S283416"},{"key":"e_1_2_8_10_1","author":"Zhao J.","year":"2021","journal-title":"Drug Delivery Transl. 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