{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:49:24Z","timestamp":1773013764233,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T00:00:00Z","timestamp":1657756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21975238"],"award-info":[{"award-number":["21975238"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Macromol. Rapid Commun."],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Lipid nanovesicles (LNVs) and polymer nanovesicles (PNVs), also known as liposomes and polymersomes, are becoming increasingly vital in global health. However, the two major classes of nanovesicles both exhibit their own issues that significantly limit potential applications. Here, by covalently attaching a naturally occurring phosphate \u201clipid head\u201d and a synthetic polylactide \u201cpolymer tail\u201d via facile ring\u2010opening polymerization on a 500 g scale, a type of \u201cchimeric\u201d nanovesicles (CNVs) can be easily produced. Compared to LNVs, the reported CNVs exhibit reduced permeability for small and large molecules; on the other hand, the CNVs are less hydrophobic and exhibit enhanced tolerance toward proteins in buffer solutions without the need for hydrophilic polymeric corona such as poly(ethylene glycol)(PEG), in contrast to conventional PNVs. The proof\u2010of\u2010concept in vitro delivery experiments using hydrophilic solutions of fluorescein\u2010PEG, rhodamine\u2010PEG, and anti\u2010cancer drug doxorubicin demonstrate that these CNVs, as a structurally diverse class of nano\u2010materials, are highly promising as alternative carriers for therapeutic molecules in translational nanomedicine.<\/jats:p>","DOI":"10.1002\/marc.202200124","type":"journal-article","created":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T22:44:12Z","timestamp":1657320252000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Lipid\u2010Head\u2010Polymer\u2010Tail Chimeric Vesicles"],"prefix":"10.1002","volume":"43","author":[{"given":"Kan","family":"Hu","sequence":"first","affiliation":[{"name":"Hefei National Laboratory for Physical Sciences at the Microscale University of Science and Technology of China  Hefei 230026 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aoyuan","family":"Cheng","sequence":"additional","affiliation":[{"name":"Hefei National Laboratory for Physical Sciences at the Microscale University of Science and Technology of China  Hefei 230026 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dingcheng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Hefei National Laboratory for Physical Sciences at the Microscale University of Science and Technology of China  Hefei 230026 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Luo","sequence":"additional","affiliation":[{"name":"Hefei National Laboratory for Physical Sciences at the Microscale University of Science and Technology of China  Hefei 230026 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