{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:57:22Z","timestamp":1789588642172,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T00:00:00Z","timestamp":1655337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008656","name":"Iketani Science and Technology Foundation","doi-asserted-by":"publisher","award":["0321035\u2010A"],"award-info":[{"award-number":["0321035\u2010A"]}],"id":[{"id":"10.13039\/501100008656","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Macromol. Rapid Commun."],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Developing nanovehicles for delivering antibiotics is a promising approach to overcome the issue of antibiotic resistance. This study aims to utilize a polyion complex (PICs) system for developing novel nanovehicles for polymyxin\u2010type antibiotics, which are known as last resort drugs. The formation of antibiotic\u2010based PIC nanostructures is investigated using colistimethate sodium (CMS), an anionic cyclic short peptide, and a series of block catiomers bearing different amounts of guanidinium moieties on their side chains. In addition, only the modified catiomer, and not the unmodified catiomer, self\u2010assembles with CMS, implying the importance of the guanidine moieties for enhancing the interaction between the catiomer and CMS via the formation of multivalent hydrogen bonding. Moreover, micellar and vesicular PIC nanostructures are selectively formed depending on the ratio of the guanidine residues. Size\u2010exclusion chromatography reveals that the encapsulation efficiency of CMS is dependent on the guanidinium modification ratio. The antimicrobial activity of the PIC nanostructures is also confirmed, indicating that the complexation of CMS in the PICs and further release from the PICs successfully occurs.<\/jats:p>","DOI":"10.1002\/marc.202200316","type":"journal-article","created":{"date-parts":[[2022,6,4]],"date-time":"2022-06-04T03:38:40Z","timestamp":1654313920000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Nanostructure Control of an Antibiotic\u2010Based Polyion Complex Using a Series of Polycations with Different Side\u2010Chain Modification Rates"],"prefix":"10.1002","volume":"43","author":[{"given":"Asmariah","family":"Ahmad","sequence":"first","affiliation":[{"name":"Department of Applied Chemistry Faculty of Engineering Kyushu University  744 Moto\u2010oka, Nishi\u2010ku Fukuoka 819\u20100395 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teruki","family":"Nii","sequence":"additional","affiliation":[{"name":"Department of Applied Chemistry Faculty of Engineering Kyushu University  744 Moto\u2010oka, Nishi\u2010ku Fukuoka 819\u20100395 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Applied Chemistry Faculty of Engineering Kyushu University  744 Moto\u2010oka, Nishi\u2010ku Fukuoka 819\u20100395 Japan"},{"name":"Center for Future Chemistry Kyushu University  744 Moto\u2010oka, Nishi\u2010ku Fukuoka 819\u20100395 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Katayama","sequence":"additional","affiliation":[{"name":"Department of Applied Chemistry Faculty of Engineering Kyushu University  744 Moto\u2010oka, Nishi\u2010ku Fukuoka 819\u20100395 Japan"},{"name":"Center for Future Chemistry Kyushu University  744 Moto\u2010oka, Nishi\u2010ku Fukuoka 819\u20100395 Japan"},{"name":"Center for Molecular Systems Kyushu University 744 Moto\u2010oka  Nishi\u2010ku Fukuoka 819\u20100395 Japan"},{"name":"Center for Advanced Medical Innovation Kyushu University 3\u20101\u20101 Maedashi  Higashi\u2010ku Fukuoka 812\u20108582 Japan"},{"name":"Department of Biomedical Engineering Chung Yuan Christian University  200 Chung Pei Rd. Chung Li 32023 Taiwan, ROC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Toyofuku","sequence":"additional","affiliation":[{"name":"Faculty of Life and Environmental Sciences University of Tsukuba  1\u20101\u20101 Tennodai Tsukuba 305\u20108572 Japan"},{"name":"Microbiology Research Center for Sustainability (MiCS) University of Tsukuba  1\u20101\u20101 Tennodai Tsukuba 305\u20108572 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0503-1418","authenticated-orcid":false,"given":"Akihiro","family":"Kishimura","sequence":"additional","affiliation":[{"name":"Department of Applied Chemistry Faculty of Engineering Kyushu University  744 Moto\u2010oka, Nishi\u2010ku Fukuoka 819\u20100395 Japan"},{"name":"Center for Future Chemistry Kyushu University  744 Moto\u2010oka, Nishi\u2010ku Fukuoka 819\u20100395 Japan"},{"name":"Center for Molecular Systems Kyushu University 744 Moto\u2010oka  Nishi\u2010ku Fukuoka 819\u20100395 Japan"},{"name":"RIKEN Center for Emergent Matter Science  2\u20101 Hirosawa Wako Saitama 351\u20100198 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,16]]},"reference":[{"key":"e_1_2_7_1_1","first-page":"277","volume":"40","author":"Ventola C. 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