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Hydrophobic cargos, such as Nile Red and chemotherapeutic drug doxorubicin, can be successfully encapsulated into the collapsed P<jats:italic>t<\/jats:italic>BA subdomains with loading capacity two orders of magnitude higher than traditional CDSA nanoparticles. Depolarized fluorescence measurements of the Nile Red loaded MCNs suggest that the free volume of the hydrophobic chains in the nanoparticles may be the key for regulating their drug loading capacity. In vitro study of the MCNs suggests excellent cytocompatibility of the blank nanoparticles as well as a dose\u2010dependent cellular uptake and cytotoxicity of the drug\u2010loaded MCNs.<\/jats:p>","DOI":"10.1002\/marc.202200706","type":"journal-article","created":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T08:38:54Z","timestamp":1668069534000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Multicompartment Nanoparticles by Crystallization\u2010Driven Self\u2010Assembly of Star Polymers: Combining High Stability and Loading Capacity"],"prefix":"10.1002","volume":"44","author":[{"given":"Haohui","family":"Huo","sequence":"first","affiliation":[{"name":"Shaanxi International Research Center for Soft Matter State Key Laboratory for Mechanical Behaviour of Materials Xi'an Jiaotong University  Xi'an 710049 P. R. 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