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Rapid Commun."],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Increasing infiltration of CD8<jats:sup>+<\/jats:sup> T cells can enhance the response rate to immune checkpoint blockade (ICB) therapies. In contrast, immunogenic cell death (ICD) induced by intracellular reactive oxygen species (ROS) is an effective strategy to increase CD8<jats:sup>+<\/jats:sup> T cell infiltration. Cuproptosis is newly defined and reported by Tsvetkov et\u00a0al. A Cu\u2010coordinated covalent organic framework (COF) in which two valence states of copper ions are simultaneously loaded is prepared. On the one hand, Cu<jats:sup>2+<\/jats:sup> undergoes a valence shift generating Cu<jats:sup>+<\/jats:sup> which acts as an effective Fenton\u2010like reagent to catalyze the production of <jats:sup>\u00b7<\/jats:sup>OH and <jats:sup>1<\/jats:sup>O<jats:sub>2<\/jats:sub> from cellular overexpressed H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>, causing DNA damage and lipid peroxidation (LPO), which directly produce cytotoxicity. On the other hand, residual Cu<jats:sup>2+<\/jats:sup> can effectively deplete endogenous cellular glutathione (GSH), converting it into glutathione disulfide (GSSG), further increasing intracellular oxidative stress and reducing the scavenging of ROS, thus further enhancing the Fenton\u2010like effect and bringing toxic effects on tumor cells. The synergy of these two functions achieves ICD, helping for transforming \u201ccold tumor\u201d into \u201chot tumor\u201d and efficient anti\u2010tumor effects eventually. This work provides new insights into coordinated COF and inspire the development of more versatile COF for biomedical applications.<\/jats:p>","DOI":"10.1002\/marc.202200929","type":"journal-article","created":{"date-parts":[[2023,2,25]],"date-time":"2023-02-25T14:43:10Z","timestamp":1677336190000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Copper\u2010Coordinated Covalent Organic Framework Produced a Robust Fenton\u2010Like Effect Inducing Immunogenic Cell Death of Tumors"],"prefix":"10.1002","volume":"44","author":[{"given":"Tong","family":"Li","sequence":"first","affiliation":[{"name":"Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied Chemistry Chinese Academy of Sciences  Changchun 130022 China"},{"name":"University of Science and Technology of China  Hefei 230026 China"},{"name":"Jilin Biomedical Polymers Engineering Laboratory  Changchun 130022 China"},{"name":"State Key Laboratory 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