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Rapid Commun."],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study demonstrates the hybridization of polyelectrolyte brushes with anti\u2010inflammatory drug\u2010loaded nanoMOFs that can achieve highly efficient aqueous lubrication and sustained drug release for the synergistic therapy of osteoarthritis (OA). Poly(3\u2010sulfopropyl methacrylate potassium salt) (PSPMK) brushes are\u00a0grown on the surface of the UiO\u201066\u2010NH<jats:sub>2<\/jats:sub> via one\u2010pot grafting polymerization, which served as a general surface modification method of NH<jats:sub>2<\/jats:sub>\u2010MOFs to grow the polymer brushes. The growth of the PSPMK brushes greatly enhance the stability, dispersity, and swollen property of the AS\u2010UiO\u201066\u2010NH2@PSPMK in aqueous media. Using as lubricating additives, the UiO\u201066\u2010NH<jats:sub>2<\/jats:sub>@PSPMK achieves not only reductions in both coefficient of friction and wear volume over 70% and 99% but also supports high load\u2010carrying capacity and long\u2010term durability. The PSPMK brushes can be served as an universal interfacial modification soft layer that can significantly improve the aqueous lubricating performance of other types of NH<jats:sub>2<\/jats:sub>\u2010MOFs. After encapsulating the anti\u2010inflammatory aspirin (AS), the AS\u2010UiO\u201066\u2010NH<jats:sub>2<\/jats:sub>@PSPMK shows both sustained drug release and good biocompatibility toward the human normal chondrocytes. This work establishes anti\u2010inflammatory drug\u2010loaded UiO\u201066\u2010NH<jats:sub>2<\/jats:sub>@PSPMK as a potential multifunctional joint lubricant for OA treatment.<\/jats:p>","DOI":"10.1002\/marc.202300089","type":"journal-article","created":{"date-parts":[[2023,3,24]],"date-time":"2023-03-24T06:42:06Z","timestamp":1679640126000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Polyelectrolyte\u2010Functionalized NanoMOFs for Highly Efficient Aqueous Lubrication and Sustained Drug Release"],"prefix":"10.1002","volume":"44","author":[{"given":"Wei","family":"Wu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Solidification Processing Center of Advanced Lubrication and Seal Materials School of Materials Science and Engineering Northwestern Polytechnical University  Xi'an 710072 P. R. 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