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While various stimuli, such as temperature, pH, light, and electromagnetic fields, have been considered for on\u2010demand release, developing drug delivery systems that are responsive to physiological\u2010level shear stresses remains as a challenge. For this purpose, liposomes embedded in hydrogel matrices are promising as they can dynamically engage with their environment due to their soft and deformable structure. However, for optimal drug delivery systems, the interaction between liposomes and the surrounding hydrogel matrix, and their response to the shear should be unraveled. Herein, we used unilamellar \u00a01,2\u2010Dimyristoyl\u2010sn\u2010glycero\u20103phosphocholine (DMPC) liposomes as drug nanocarriers and polyethylene (glycol) diacrylate (PEGDA) hydrogels having different elasticities, from 1 to 180\u00a0Pa, as extracellular matrix (ECM)\u2010mimetic matrices to understand shear\u2010triggered liposome discharge from hydrogels. The presence of liposomes provides hydrogels with temperature\u2010controlled water uptake which is sensitive to membrane microviscosity. By systematically applying shear deformation from linear to nonlinear deformation regimes, the liposome release under transient and cyclic stimuli is modulated. Considering that shear force is commonly encountered in biofluid flow, these results will provide fundamental basis for rational design of shear\u2010controlled liposomal drug delivery systems.<\/jats:p>","DOI":"10.1002\/marc.202300090","type":"journal-article","created":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T13:29:09Z","timestamp":1681910949000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Shear\u2010Triggered Release of Lipid Nanoparticles from Tissue\u2010Mimetic Hydrogels"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9161-0765","authenticated-orcid":false,"given":"Selcan","family":"Karaz","sequence":"first","affiliation":[{"name":"Department of Chemical and Biological Engineering Koc University  Sariyer Istanbul 34450 Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gizem","family":"Akay","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering Koc University  Sariyer Istanbul 34450 Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ismail C.","family":"Karaoglu","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biological Engineering Koc University  Sariyer Istanbul 34450 Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mertcan","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Electrical and Electronics Engineering Koc University  Istanbul 34450 Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sedat","family":"Nizamoglu","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering Koc University  Sariyer Istanbul 34450 Turkey"},{"name":"Department of Electrical and Electronics Engineering Koc University  Istanbul 34450 Turkey"},{"name":"Graduate School of Biomedical Science and Engineering Koc University  Istanbul 34450 Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9092-2698","authenticated-orcid":false,"given":"Seda","family":"Kizilel","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biological Engineering Koc University  Sariyer Istanbul 34450 Turkey"},{"name":"Department of Materials Science and Engineering Koc University  Sariyer Istanbul 34450 Turkey"},{"name":"Graduate School of Biomedical Science and Engineering Koc University  Istanbul 34450 Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2593-1146","authenticated-orcid":false,"given":"Erkan","family":"Senses","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biological Engineering Koc University  Sariyer Istanbul 34450 Turkey"},{"name":"Koc University Surface Science and Technology Center (KUYTAM)  Istanbul 34450 Turkey"},{"name":"Koc University Boron and Advanced Materials Application and Research Center (KUBAM)  Istanbul 34450 Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,5,5]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202002196"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25092193"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvt102"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2004.09.030"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.17.4.646"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2005.01.020"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpcardio1397"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3330"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.01.007"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.anchem.1.031207.112747"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2013.06.022"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp4001298"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(92)90392-Y"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2004.12.019"},{"key":"e_1_2_9_15_1","first-page":"267","volume-title":"Non\u2010Viral Gene Therapy","author":"Julia E. 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