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To avoid this problem and to further extend the properties of these homopolymers, the synthesis of a new graft copolymer, the fully biodegradable amphiphilic poly(<jats:italic>\u03b5<\/jats:italic>\u2010caprolactone<jats:italic>\u2010g\u2010<\/jats:italic>chitosan) (PCL<jats:italic>\u2010g\u2010<\/jats:italic>CHT) is described, with an unusual \u201creverse\u201d structure formed by a PCL backbone with CHT grafts, unlike the \u201cclassic\u201d CHT\u2010<jats:italic>g<\/jats:italic>\u2010PCL structure with a CHT main chain and PCL grafts. This copolymer is prepared via a copper\u2010catalyzed 1,3\u2010dipolar Huisgen cycloaddition between propargylated PCL (PCL\u2010yne) and a new azido\u2010chitosan (CHT\u2010N<jats:sub>3<\/jats:sub>). In order to obtain an amphiphilic copolymer regardless of the pH, chitosan oligomers, soluble at any pH, are prepared and used. The amphiphilic PCL<jats:italic>\u2010g\u2010<\/jats:italic>CHT copolymer spontaneously self\u2010assembles in water into nanomicelles that may incorporate hydrophobic drugs to give novel drug delivery systems.<\/jats:p>","DOI":"10.1002\/marc.202300156","type":"journal-article","created":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T11:29:29Z","timestamp":1681903769000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Synthesis of a New Poly(<i>\u03b5<\/i>\u2010caprolactone)\u2010<i>g<\/i>\u2010Chitosan Amphiphilic Graft Copolymer with a \u201cReverse\u201d Structure"],"prefix":"10.1002","volume":"44","author":[{"given":"Victor","family":"Delorme","sequence":"first","affiliation":[{"name":"IBMM (Institut des Biomol\u00e9cules Max Mousseron) CNRS Department Polymers for Health and Biomaterials Montpellier University ENSCM P\u00f4le Chimie Balard  1919 route de Mende cedex 5 Montpellier 34090 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