{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:45:09Z","timestamp":1790912709230,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001824","name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["22\u201002836S"],"award-info":[{"award-number":["22\u201002836S"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Macromol. Rapid Commun."],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study presents a systematic comparison of the antifouling properties of water\u2010soluble poly(2\u2010oxazoline) (PAOx) and poly(2\u2010oxazine) (PAOzi) brushes grafted to gold surfaces. PAOx and PAOzi are emerging polymer classes in biomedical sciences and are being considered superior alternatives to widely used polyethylene glycol (PEG). Four different polymers, poly(2\u2010methyl\u20102\u2010oxazoline) (PMeOx), poly(2\u2010ethyl\u20102\u2010oxazoline) (PEtOx), poly(2\u2010methyl\u20102\u2010oxazine) (PMeOzi), and poly(2\u2010ethyl\u20102\u2010oxazine) (PEtOzi), each of them in three different chain lengths, are synthesized and characterized for their antifouling properties. Results show that all polymer\u2010modified surfaces display better antifouling properties than bare gold surfaces as well as analogous PEG coatings. The antifouling properties increase in the following order: PEtOx\u00a0&lt;\u00a0PMeOx\u00a0\u2248 PMeOzi\u00a0&lt;\u00a0PEtOzi. The study suggests that the resistance to protein fouling derives from both surface hydrophilicity and the molecular structural flexibility of the polymer brushes. PEtOzi brushes with moderate hydrophilicity show the best antifouling performance, possibly due to their highest chain flexibility. Overall, the research contributes to the understanding of antifouling properties in PAOx and PAOzi polymers, with potential applications in various biomaterials.<\/jats:p>","DOI":"10.1002\/marc.202300168","type":"journal-article","created":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T20:49:35Z","timestamp":1684874975000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Antifouling Properties of Poly(2\u2010Oxazoline)s and Poly(2\u2010Oxazine)s: Direct Comparison of Polymer\u2010Coated Surfaces with the Same Coating Parameters"],"prefix":"10.1002","volume":"44","author":[{"given":"Jan","family":"Svoboda","sequence":"first","affiliation":[{"name":"Institute of Macromolecular Chemistry, v.v.i. Academy of Sciences of the Czech Republic Prague 6 162 00 Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niccolo","family":"Lusiani","sequence":"additional","affiliation":[{"name":"Department of Physical and Macromolecular Chemistry, Faculty of Science Charles University Prague 2 128 00 Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radoslava","family":"Sivkova","sequence":"additional","affiliation":[{"name":"Institute of Macromolecular Chemistry, v.v.i. Academy of Sciences of the Czech Republic Prague 6 162 00 Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7938-9271","authenticated-orcid":false,"given":"Ognen","family":"Pop\u2010Georgievski","sequence":"additional","affiliation":[{"name":"Institute of Macromolecular Chemistry, v.v.i. 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