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Rapid Commun."],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This work introduces a novel multifunctional system called UPIPF (upconversion\u2010polydopamine\u2010indocyanine\u2010polyethylene\u2010folic) for upconversion luminescent (UCL) imaging of cancer cells using near\u2010infrared (NIR) illumination. The system demonstrates efficient inhibition of human hepatoma (HepG2) cancer cells through a combination of NIR\u2010triggered photodynamic therapy (PDT) and enhanced photothermal therapy (PTT). Initially, upconversion nanoparticles (UCNP) are synthesized using a simple thermal decomposition method. To improve their biocompatibility and aqueous dispersibility, polydopamine (PDA) is introduced to the UCNP via a ligand exchange technique. Indocyanine green (ICG) molecules are electrostatically attached to the surface of the UCNP\u2010polydopamine (UCNP@PDAs) complex to enhance the PDT and PTT effects. Moreover, polyethylene glycol (PEG)\u2010modified folic acid (FA) is incorporated into the UCNP\u2010polydopamine\u2010indocyanine\u2010green (UCNP@PDA\u2010ICGs) nanoparticles to enhance their targeting capability against cancer cells. The excellent UCL properties of these UCNP enable the final UCNP@PDA\u2010ICG\u2010PEG\u2010FA nanoparticles (referred to as UPIPF) to serve as a potential candidate for efficient anticancer drug delivery, real\u2010time imaging, and early diagnosis of cancer cells. Furthermore, the UPIPF system exhibits PDT\u2010assisted PTT effects, providing a convenient approach for efficient cancer cell inhibition (more than 99% of cells are killed). The prepared UPIPF system shows promise for early diagnosis and simultaneous treatment of malignant cancers.<\/jats:p>","DOI":"10.1002\/marc.202300298","type":"journal-article","created":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T08:55:58Z","timestamp":1691398558000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Simultaneous Imaging and Photodynamic\u2010Enhanced Photothermal Inhibition of Cancer Cells Using a Multifunctional System Combining Indocyanine Green and Polydopamine\u2010Preloaded Upconversion Luminescent Nanoparticles"],"prefix":"10.1002","volume":"44","author":[{"given":"Sihao","family":"Ye","sequence":"first","affiliation":[{"name":"Laboratory of Nanoscale Biosensing and Bioimaging (NBAB) School of Ophthalmology and Optometry School of Biomedical Engineering Wenzhou Medical University  Wenzhou Zhejiang 325027 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Laboratory of Nanoscale Biosensing and Bioimaging (NBAB) School of Ophthalmology and Optometry School of Biomedical Engineering Wenzhou Medical University  Wenzhou Zhejiang 325027 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology the Second Affiliated Hospital of Wenzhou Medical University Wenzhou Medical University  Wenzhou Zhejiang 325027 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuai","family":"Han","sequence":"additional","affiliation":[{"name":"Laboratory of Nanoscale Biosensing and Bioimaging (NBAB) School of Ophthalmology and Optometry School of Biomedical Engineering Wenzhou Medical University  Wenzhou Zhejiang 325027 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai","family":"Hu","sequence":"additional","affiliation":[{"name":"Laboratory of Nanoscale Biosensing and Bioimaging (NBAB) School of Ophthalmology and Optometry School of Biomedical Engineering Wenzhou Medical University  Wenzhou Zhejiang 325027 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuexiang","family":"Liang","sequence":"additional","affiliation":[{"name":"Laboratory of Nanoscale Biosensing and Bioimaging (NBAB) School of Ophthalmology and Optometry School of Biomedical Engineering Wenzhou Medical University  Wenzhou Zhejiang 325027 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zijian","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology the Second Affiliated Hospital of Wenzhou Medical University Wenzhou Medical University  Wenzhou Zhejiang 325027 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuepeng","family":"Jin","sequence":"additional","affiliation":[{"name":"National Key Clinical Specialty (General Surgery) the First Affiliated Hospital of Wenzhou Medical University Wenzhou Medical University  Wenzhou Zhejiang 325000 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom","family":"Lawson","sequence":"additional","affiliation":[{"name":"School of Mathematical and Physical Sciences ARC Centre of Excellence for Nanoscale Biophotonics (CNBP) Macquarie University  Sydney NSW 2109 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6932-583X","authenticated-orcid":false,"given":"Yong","family":"Liu","sequence":"additional","affiliation":[{"name":"Laboratory of Nanoscale Biosensing and Bioimaging (NBAB) School of Ophthalmology and Optometry School of Biomedical Engineering Wenzhou Medical University  Wenzhou Zhejiang 325027 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenzhai","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology the Second Affiliated Hospital of Wenzhou Medical University Wenzhou Medical University  Wenzhou Zhejiang 325027 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8,21]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b03212"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201800377"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20184454"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar200023x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2933"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja404985w"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201601289"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202004161"},{"key":"e_1_2_8_9_1","volume":"9","author":"He X.","year":"2022","journal-title":"Adv. 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