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Rapid Commun."],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Imbalanced immune regulation leads to the abnormal wound healing process, e.g., chronic unhealing wound or hypertrophic scar formation. Thus, the attenuation of the overflowing inflammatory factors is a viable approach to maintain the homeostatic immune regulation to facilitate normal wound healing.\u00a0A versatile telodendrimer (TD) nanotrap (NT) platform is developed for efficient biomolecular protein binding. The conjugation of TD NT in size\u2010exclusive biocompatible hydrogel resin allows for topical application for cytokine scavenging. Fine\u2010tuning the TD NT density\/valency in hydrogel resin controls resin swelling, optimizes molecular diffusion, and improves cytokine capture for effective immune modulation. The hydrogel with reduced TD NT density allows for higher protein\/cytokine adsorption capacity with faster kinetics, due to the reduced barrier\u00a0of TD NT nano\u2010assembly. The positively charged TD NT hydrogel exhibits superior removal of negatively charged proinflammatory cytokines from the lipopolysaccharide (LPS, a potent endotoxin) primed immune cell culture medium. The negatively charged TD NT hydrogel removes positively charged anti\u2010inflammatory cytokines efficiently from cell culture medium. TD NT hydrogel effectively constrains the local inflammation induced by subcutaneous LPS injection in mice. These results indicate the great potential applications of the engineered TD NT hydrogel as topical immune modulatory treatments to attenuate local inflammation.<\/jats:p>","DOI":"10.1002\/marc.202300322","type":"journal-article","created":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T00:46:28Z","timestamp":1691023588000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Engineering Nanotrap Hydrogel for Immune Modulation in Wound Healing"],"prefix":"10.1002","volume":"44","author":[{"given":"Xiguang","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Pharmacology State University of New York Upstate Medical University  Syracuse NY 13210 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Pharmacology State University of New York Upstate Medical University  Syracuse NY 13210 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotian","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Pharmacology State University of New York Upstate Medical University  Syracuse NY 13210 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changying","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology State University of New York Upstate Medical University  Syracuse NY 13210 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3538-9453","authenticated-orcid":false,"given":"Juntao","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Pharmacology State University of New York Upstate Medical University  Syracuse NY 13210 USA"},{"name":"Department of Surgery State University of New York Upstate Medical University  Syracuse NY 13210 USA"},{"name":"Department of Immunology and Microbiology State University of New York Upstate Medical University  Syracuse NY 13210 USA"},{"name":"Upstate Cancer Center State University of New York Upstate Medical University  Syracuse NY 13210 USA"},{"name":"Upstate Sepsis Interdisciplinary Research Center State University of New York Upstate Medical University  Syracuse NY 13210 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,15]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3009337"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034509359125"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2005.01.006"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700701"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI44490"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aai9044"},{"key":"e_1_2_9_7_1","first-page":"4391","volume":"14","author":"Kandhwal M.","year":"2022","journal-title":"Am. 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