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Rapid Commun."],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Biocompatible chitosan\u2010based hydrogels have attracted extensive attention in wound dressing due to their human skin\u2010like tissue characteristics. However, it is a crucial challenge to fabricate chitosan\u2010based hydrogels with versatile properties, including flexibility, stretchability, adhesivity, and antibacterial activity. In this work, a kind of chitosan\u2010based hydrogels with integrated functionalities are facilely prepared by solution polymerization of acrylamide (AAm) and sodium\n                    <jats:italic>p<\/jats:italic>\n                    \u2010styrene sulfonate (SS) in the presence of quaternized carboxymethyl chitosan (QCMCS). Due to the dual cross\u2010linking between QCMCS and P(AAm\n                    <jats:italic>\u2010co\u2010<\/jats:italic>\n                    SS), the optimized QCMCS\/P(AAm\u2010\n                    <jats:italic>co<\/jats:italic>\n                    \u2010SS) hydrogel exhibits tough mechanical properties (0.767\u00a0MPa tensile stress and 1100% fracture strain) and moderate tissue adhesion (11.4\u00a0kPa). Moreover, biological evaluation in vitro illustrated that as\u2010prepared hydrogel possesses satisfactory biocompatibility, hemocompatibility, and excellent antibacterial ability (against\n                    <jats:italic>S. aureus<\/jats:italic>\n                    and\n                    <jats:italic>E. coli<\/jats:italic>\n                    are 98.8% and 97.3%, respectively). Then, the hydrogels are tested in a rat model for bacterial infection incision in vivo, and the results show that they can significantly accelerate epidermal regeneration and wound closure. This is due to their ability to reduce the inflammatory response, promote the formation of collagen deposition and granulation tissue. The proposed chitosan\u2010based antibacterial hydrogels have the potential to be a highly effective wound dressing in clinical wound healing.\n                  <\/jats:p>","DOI":"10.1002\/marc.202300325","type":"journal-article","created":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T15:05:25Z","timestamp":1691766325000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Dual\u2010Cross\u2010Linked Chitosan\u2010Based Antibacterial Hydrogels with Tough and Adhesive Properties for Wound Dressing"],"prefix":"10.1002","volume":"44","author":[{"given":"Jingjing","family":"Du","sequence":"first","affiliation":[{"name":"Hunan Key Laboratory of Biomedical Nanomaterials and Devices College of Life Science and Chemistry Hunan University of Technology  Zhuzhou 412007 China"},{"name":"College of Packaging Materials and Engineering Hunan University of Technology  Zhuzhou 412007 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hunan Key Laboratory of Biomedical Nanomaterials and Devices College of Life Science and Chemistry Hunan University of Technology  Zhuzhou 412007 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilin","family":"Huang","sequence":"additional","affiliation":[{"name":"Hunan Key Laboratory of Biomedical Nanomaterials and Devices College of Life Science and Chemistry Hunan University of Technology  Zhuzhou 412007 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hunan Key Laboratory of Biomedical Nanomaterials and Devices College of Life Science and Chemistry Hunan University of Technology  Zhuzhou 412007 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzhi","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Packaging Materials and Engineering Hunan University of Technology  Zhuzhou 412007 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maolin","family":"Yu","sequence":"additional","affiliation":[{"name":"Hunan Key Laboratory of Biomedical Nanomaterials and Devices College of Life Science and Chemistry Hunan University of Technology  Zhuzhou 412007 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijian","family":"Xu","sequence":"additional","affiliation":[{"name":"Hunan Key Laboratory of Biomedical Nanomaterials and Devices College of Life Science and Chemistry Hunan University of Technology  Zhuzhou 412007 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5811-6880","authenticated-orcid":false,"given":"Jianxiong","family":"Xu","sequence":"additional","affiliation":[{"name":"Hunan Key Laboratory of Biomedical Nanomaterials and Devices College of Life Science and Chemistry Hunan University of Technology  Zhuzhou 412007 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,21]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0BM00055H"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.0c01548"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1253836"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2004.02.002"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemmater.0c02030"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c00204"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2021.130302"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S371900"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmapro.2017.08.001"},{"key":"e_1_2_7_10_1","volume":"30","author":"Yao X.","year":"2020","journal-title":"Adv. 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