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The presence of a fluorescent sensing group on polymer\u2010bound squaramides allowed for a fluorescent sensing mechanism for anions that followed a similar trend in selectivity in aqueous DMSO solution, with selectivity observed for H<jats:sub>2<\/jats:sub>PO<jats:sub>4<\/jats:sub><jats:sup>\u2212<\/jats:sup>, AcO<jats:sup>\u2212<\/jats:sup> and SO<jats:sub>4<\/jats:sub><jats:sup>2\u2212<\/jats:sup> over other common anions tested. The anion response and selectivity towards anions is similar to that of analogous small\u2010molecule squaramides, however polymeric squaramides exhibited a greater resistance to deprotonation by more basic anions, which is attributed to the closer proximity of individual squaramides on a macromolecule. The squaramide\u2010containing polymers exhibited good water solubility, overcoming a common problem for anion sensors which are typically not sufficiently soluble in water to function in many required applications. Despite no anion binding being observed in water, this study represents a simple and effective method of creating fully water\u2010soluble anion receptors which may be adapted to give improved binding affinity and selectivity depending on the anion binding moiety.<\/jats:p>","DOI":"10.1002\/marc.202300406","type":"journal-article","created":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T00:34:21Z","timestamp":1695170061000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Water\u2010Soluble Squaramide\u2010Functionalized Copolymers for Anion Recognition"],"prefix":"10.1002","volume":"46","author":[{"given":"Jakob D. 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