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Rapid Commun."],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>N\u2010carboxyanhydride ring\u2010opening polymerization\u2010induced self\u2010assembly (NCA ROPISA) offers a convenient route for generating poly(amino acid)\u2010based nanoparticles in a single step, crucially avoiding the need for post\u2010polymerization self\u2010assembly. Most examples of NCA ROPISA make use of a poly(ethylene glycol) (PEG) hydrophilic stabilizing block, however this\u00a0non\u2010biodegradable, oil\u2010derived polymer may cause an immunological response in some individuals. Alternative water\u2010soluble polymers are therefore highly sought. This work reports the synthesis of wholly poly(amino acid)\u2010based nanoparticles, through the chain\u2010extension of a polysarcosine macroinitiator with L\u2010Phenylalanine\u2010NCA (L\u2010Phe\u2010NCA) and Alanine\u2010NCA (Ala\u2010NCA), via aqueous NCA ROPISA. The resulting polymeric structures comprise of predominantly anisotropic, rod\u2010like nanoparticles, with morphologies primarily influenced by the secondary structure of the hydrophobic poly(amino acid) that enables their formation.<\/jats:p>","DOI":"10.1002\/marc.202400103","type":"journal-article","created":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T10:00:23Z","timestamp":1712743223000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["The Production of Polysarcosine\u2010Containing Nanoparticles by Ring\u2010Opening Polymerization\u2010Induced Self\u2010Assembly"],"prefix":"10.1002","volume":"45","author":[{"given":"Anna H.","family":"Morrell","sequence":"first","affiliation":[{"name":"School of Chemical and Process Engineering University of Leeds  Leeds LS2 9JT UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8298-1417","authenticated-orcid":false,"given":"Nicholas J.","family":"Warren","sequence":"additional","affiliation":[{"name":"School of Chemical and Process Engineering University of Leeds  Leeds LS2 9JT UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3876-1617","authenticated-orcid":false,"given":"Paul D.","family":"Thornton","sequence":"additional","affiliation":[{"name":"Leeds Institute of Textiles and Colour (LITAC) School of Design University of Leeds  Leeds LS2 9JT UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,25]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja410593n"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7SC04788F"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/ma301059r"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.macromol.5b02602"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202207457"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202308372"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.progpolymsci.2015.05.001"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrp.2023.101495"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmacrolett.9b00464"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/agt2.418"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0PY00455C"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja501756h"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5PY00157A"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.macromol.5b00576"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b07953"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0SC00569J"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0PY00562B"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1PY00045D"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/ma300898e"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201200925"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1039\/C3PY01719B"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.macromol.9b02697"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja206301a"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5PY00656B"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.macromol.6b02643"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b06788"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202207376"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201000095"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9PY00498J"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.macromol.0c02106"},{"key":"e_1_2_8_31_1","first-page":"1528","volume":"28","author":"Delaittre G.","year":"2007","journal-title":"Macro Molecular"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/ma5019473"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.macromol.0c00371"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0PY00296H"},{"key":"e_1_2_8_35_1","volume":"40","author":"Wright D. 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