{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T21:58:26Z","timestamp":1788904706508,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T00:00:00Z","timestamp":1714003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32071375"],"award-info":[{"award-number":["32071375"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFF0713900"],"award-info":[{"award-number":["2023YFF0713900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing Municipality","doi-asserted-by":"publisher","award":["CSTB2022NSCQ\u2010MSX1479"],"award-info":[{"award-number":["CSTB2022NSCQ\u2010MSX1479"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Macromol. Rapid Commun."],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this work, a natural medicine, baicalin, is designed for the treatment of psoriasis with the aid of hyaluronic acid (HA)\u2010based MNs patches. This is also to improve the solubility of baicalin and increase its residence time in infected part, which is made into nanoparticles by complexation with humic acid and Eu<jats:sup>2+<\/jats:sup>. The baicalin nanoparticles loaded\u2010MNs exhibit satisfactory rigidity, minimum injury, and controlled drug delivery. The anti\u2010reactive oxygen species (anti\u2010ROS) and anti\u2010inflammatory action are verified by the effective scavenging oxygen and nitrogen radicals. In addition, the loading of baicalin nanoparticles brings remarkable photothermic effect to the MNs, enabling the device to release a controlled drug under near\u2010infrared region II (NIR\u2010II) laser irradiation. With the aid of NIR\u2010II laser, the baicalin\u2010mediated treatment of psoriasis is significantly improved by expediting radical scavenging and suppressing inflammation. The design of baicalin MNs provides a new idea for the treatment of chronic disease.<\/jats:p>","DOI":"10.1002\/marc.202400136","type":"journal-article","created":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T18:58:37Z","timestamp":1712689117000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Anti\u2010ROS and NIR\u2010II\u2010Responsive Hyaluronic Acid Microneedle Loaded With Baicalin Nanoparticles for Treatment of Psoriasis"],"prefix":"10.1002","volume":"45","author":[{"given":"Chuanlan","family":"Xia","sequence":"first","affiliation":[{"name":"Key Laboratory of Luminescence Analysis and Molecular Sensing School of Materials and Energy Southwest University  Chongqing 400715 China"},{"name":"Yibin Academy of Southwest University  Yibin 644000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinwei","family":"Fu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Luminescence Analysis and Molecular Sensing School of Materials and Energy Southwest University  Chongqing 400715 China"},{"name":"Yibin Academy of Southwest University  Yibin 644000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Luminescence Analysis and Molecular Sensing School of Materials and Energy Southwest University  Chongqing 400715 China"},{"name":"Yibin Academy of Southwest University  Yibin 644000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Luminescence Analysis and Molecular Sensing School of Materials and Energy Southwest University  Chongqing 400715 China"},{"name":"Yibin Academy of Southwest University  Yibin 644000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiucun","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Luminescence Analysis and Molecular Sensing School of Materials and Energy Southwest University  Chongqing 400715 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuejun","family":"Kang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Luminescence Analysis and Molecular Sensing School of Materials and Energy Southwest University  Chongqing 400715 China"},{"name":"Yibin Academy of Southwest University  Yibin 644000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4903-2161","authenticated-orcid":false,"given":"Bin","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Luminescence Analysis and Molecular Sensing School of Materials and Energy Southwest University  Chongqing 400715 China"},{"name":"Yibin Academy of Southwest University  Yibin 644000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,25]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2003.10.023"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2017.02.040"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b15668"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202205847"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adg6007"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c08979"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2003.00751.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20060244"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.09.064"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.1c02899"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2021.02.057"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.3c00058"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1015948505117"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvh134"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1998.275.6.C1640"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2007.00112.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0423-0"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.02.012"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2021.133956"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.07.015"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(18)35492-5"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1216"},{"key":"e_1_2_9_23_1","author":"Yang X.","year":"2013","journal-title":"Clin. Dev. Immunol."},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2013.03.006"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-016-0294-1"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep32225"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep17407"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01959410"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-78498-6"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0269-7491(91)90009-L"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12274-022-5199-0"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202114722"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-023-02124-6"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c05075"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/es0534046"},{"key":"e_1_2_9_36_1","first-page":"231","volume":"1","author":"Lu T.","year":"2021","journal-title":"ChemRxiv"},{"key":"e_1_2_9_37_1","first-page":"1298","volume":"1","author":"Ma C.","year":"2023","journal-title":"J. Mol. Struct."},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-34248-y"},{"key":"e_1_2_9_39_1","first-page":"9","volume":"21","author":"Jun G.","year":"2005","journal-title":"China J. Lepr. Skin Dis."}],"container-title":["Macromolecular Rapid Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/marc.202400136","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T17:29:20Z","timestamp":1723051760000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/marc.202400136"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,25]]},"references-count":39,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1002\/marc.202400136"],"URL":"https:\/\/doi.org\/10.1002\/marc.202400136","archive":["Portico"],"relation":{},"ISSN":["1022-1336","1521-3927"],"issn-type":[{"value":"1022-1336","type":"print"},{"value":"1521-3927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,25]]},"assertion":[{"value":"2024-03-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2400136"}}