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Rapid Commun."],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Osteoarthritis (OA) is a chronic degenerative joint disease characterized by the degradation of articular cartilage. Recent studies have demonstrated that chondrocyte ferroptosis plays a crucial role in the progression of OA. Consequently, developing nanomedicines that suppress chondrocyte ferroptosis is a promising strategy for OA treatment. However, there are few reports on nanomedicines specifically targeting chondrocyte ferroptosis for OA therapy. In this study, Curcumin\u2010loaded nanoparticles (Cur\u2010NPs) are fabricated to suppress chondrocyte ferroptosis by regulating reactive oxygen species (ROS), ferrous ion (Fe<jats:sup>2<\/jats:sup>\u207a), and Acyl\u2010CoA Synthetase Long\u2010Chain Family Member 4 (ACSL4) levels of chondrocyte. This is achieved by combining the functions of curcumin and an amphiphilic block copolymer with ROS scavenging and iron\u2010chelating properties. The in vitro anti\u2010ferroptotic effects of Cur\u2010NPs are thoroughly investigated. The findings indicate that Cur\u2010NPs decrease the expression of ferroptosis markers such as ROS, Fe<jats:sup>2<\/jats:sup>\u207a, and ACSL4, while protecting the mitochondrial membrane potential of chondrocytes. Additionally, Cur\u2010NPs attenuated lipid peroxidation in chondrocytes. Furthermore, Cur\u2010NPs significantly reduced the expression of the catabolic factor Matrix Metallopeptidase 13 (MMP13) and increased the expression of the anabolic factor Collagen type II (Col II) in vitro. This study demonstrates that Cur\u2010NPs exhibit enhanced chondroprotective effects through anti\u2010ferroptotic actions, presenting a promising approach for inhibiting chondrocyte ferroptosis using bioactive nanomaterials in OA treatment.<\/jats:p>","DOI":"10.1002\/marc.202400495","type":"journal-article","created":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T18:03:39Z","timestamp":1726682619000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["A Novel Curcumin\u2010Loaded Nanoplatform Alleviates Osteoarthritis by Inhibiting Chondrocyte Ferroptosis"],"prefix":"10.1002","volume":"46","author":[{"given":"Weibei","family":"Sheng","sequence":"first","affiliation":[{"name":"Department of Bone &amp; Joint Surgery National &amp; Local Joint Engineering Research Center of Orthopedic Biomaterials Shenzhen Key Laboratory of Orthopedic Diseases and Biomaterials Research Peking University Shenzhen Hospital  Shenzhen 518036 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aikang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Bone &amp; 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