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While the PEGylation reaction on polar surfaces is widely used and regarded as a common technique, the PEGylation on less polar polymers and elastomers is extremely difficult due to the absence of reactive points with PEG terminus. Herein, the design and synthesis of an orthogonal agent with a nitrile <jats:italic>N<\/jats:italic>\u2010oxide and a phenyl carbamate that can mediate between an alkene and an amine are reported. The ligation capacity of the orthogonal agent is demonstrated through the model reaction to connect between 1\u2010hexene and 4\u2010methoxybenzylamine and the grafting reaction of PEG onto poly(styrene\u2010<jats:italic>co<\/jats:italic>\u2010butadiene) (SB) resin. The surface characteristics of PEGylated SB film are evaluated by X\u2010ray photoelectron spectroscopy (XPS) and contact angle measurements. Because SB resin is frequently used as a 3D\u2010printing polymer, the present study indicates that the orthogonal agent can be applicable to the surface modification of 3D\u2010printed objects precisely manufactured by using a computer\u2010aided design (CAD) file in the future.<\/jats:p>","DOI":"10.1002\/marc.202400555","type":"journal-article","created":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T14:49:13Z","timestamp":1731509353000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Orthogonal Agent Comprising a Nitrile <i>N<\/i>\u2010Oxide and a Phenylcarbamate for Facile Molecular Integration on Styrne\u2010Butadiene Resin"],"prefix":"10.1002","volume":"46","author":[{"given":"Sota","family":"Nozawa","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Engineering Toyama Prefectural University  5180 Kurokawa Imizu Toyama 939\u20100398 Japan"},{"name":"Biotechnology Research Center Toyama Prefectural University  5180 Kurokawa Imizu Toyama 939\u20100398 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriyuki","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Engineering Toyama Prefectural University  5180 Kurokawa Imizu Toyama 939\u20100398 Japan"},{"name":"Biotechnology Research Center Toyama Prefectural University  5180 Kurokawa Imizu Toyama 939\u20100398 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Hamada","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Engineering Toyama Prefectural University  5180 Kurokawa Imizu Toyama 939\u20100398 Japan"},{"name":"Biotechnology Research Center Toyama Prefectural University  5180 Kurokawa Imizu Toyama 939\u20100398 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6985-4499","authenticated-orcid":false,"given":"Yasuhito","family":"Koyama","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Engineering Toyama Prefectural University  5180 Kurokawa Imizu Toyama 939\u20100398 Japan"},{"name":"Biotechnology Research Center Toyama Prefectural University  5180 Kurokawa Imizu Toyama 939\u20100398 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,13]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/9783527655427"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.progpolymsci.2004.05.002"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6700(02)00032-1"},{"key":"e_1_2_8_2_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbon.2006.02.038"},{"key":"e_1_2_8_2_4","doi-asserted-by":"publisher","DOI":"10.1039\/b808639g"},{"key":"e_1_2_8_2_5","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6700(00)00012-5"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr9901337"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200902672"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2015.09.012"},{"key":"e_1_2_8_4_3","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21031007"},{"key":"e_1_2_8_4_4","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2017.07.015"},{"key":"e_1_2_8_4_5","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1033"},{"key":"e_1_2_8_4_6","doi-asserted-by":"publisher","DOI":"10.1016\/j.xphs.2015.11.015"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pol.20210126"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/med.20107"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja0711617"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja050310n"},{"key":"e_1_2_8_6_3","doi-asserted-by":"publisher","DOI":"10.1021\/ja0549751"},{"key":"e_1_2_8_6_4","doi-asserted-by":"publisher","DOI":"10.1039\/b510282k"},{"key":"e_1_2_8_6_5","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200904936"},{"key":"e_1_2_8_6_6","doi-asserted-by":"publisher","DOI":"10.1039\/c0py00004c"},{"key":"e_1_2_8_6_7","doi-asserted-by":"publisher","DOI":"10.1021\/ma2005102"},{"key":"e_1_2_8_6_8","doi-asserted-by":"publisher","DOI":"10.1021\/ja108441d"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3cc42992j"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/mz500069f"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pi.1314"},{"key":"e_1_2_8_9_1","volume":"223","author":"Ooba S.","year":"2022","journal-title":"Chem. 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