{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:49:56Z","timestamp":1786978196656,"version":"build-2736575974"},"reference-count":42,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T00:00:00Z","timestamp":1726099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Macromol. Rapid Commun."],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Glioblastoma is one of the most aggressive and treatment\u2010resistant forms of primary brain cancer, posing significant challenges in effective therapy. This study aimed to enhance the effectiveness of glioblastoma therapy by developing a unique nanomedicine composed of Pluronic F127\u2010complexed PEGylated poly(glutamic acid)\u2010cisplatin (PLG\u2010PEG\/PF127\u2010CDDP). PLG\u2010PEG\/PF127\u2010CDDP demonstrated an optimal size of 133.97\u00a0\u00b1\u00a012.60\u00a0nm, facilitating efficient cell uptake by GL261 glioma cells. In vitro studies showed significant cytotoxicity against glioma cells with a half\u2010maximal (50%) inhibitory concentration (IC50) of 12.61\u00a0\u00b5g\u00a0mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    at 48\u00a0h and a 72.53%\u00a0\u00b1\u00a01.89% reduction in cell invasion. Furthermore, PLG\u2010PEG\/PF127\u2010CDDP prolonged the circulation half\u2010life of cisplatin to 9.75\u00a0h in vivo, leading to a more than 50% reduction in tumor size on day 16 post\u2010treatment initiation in a murine model of glioma. The treatment significantly elevated lactate levels in GL261 cells, indicating enhanced metabolic disruption. Therefore, PLG\u2010PEG\/PF127\u2010CDDP offers a promising approach for glioblastoma therapy due to its effects on improving drug delivery efficiency, therapeutic outcomes, and safety while minimizing systemic side effects. This work underscores the potential of polymer\u2010based nanomedicines in overcoming the challenges of treating brain tumors, paving the way for future clinical applications.\n                  <\/jats:p>","DOI":"10.1002\/marc.202400662","type":"journal-article","created":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T11:43:19Z","timestamp":1726141399000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Pluronic F127\u2010Complexed PEGylated Poly(glutamic acid)\u2010Cisplatin Nanomedicine for Enhanced Glioblastoma Therapy"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4333-0559","authenticated-orcid":false,"given":"Xiaoyu","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Neurosurgery the First Hospital of Jilin University  1 Xinmin Street Changchun 130061 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0606-9119","authenticated-orcid":false,"given":"Jiaxue","family":"Liu","sequence":"additional","affiliation":[{"name":"Jilin Collaborative Innovation Center for Antibody Engineering Jilin Medical University  5 Jilin Street Jilin 132000 P. R. China"},{"name":"Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied Chemistry Chinese Academy of Sciences  5625 Renmin Street Changchun 130022 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2199-8618","authenticated-orcid":false,"given":"Yunqian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery the First Hospital of Jilin University  1 Xinmin Street Changchun 130061 P. R. 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