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Rapid Commun."],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Macromolecules exhibit rich phase behavior that may be exploited for advanced material design. In particular, the volume phase transition in certain crosslinked hydrogels is a key property controlling the transition between a collapsed\/dehydrated and a swollen\/hydrated state, thereby regulating the release and absorption of water via a temperature change. In this work, a simple and tunable system exhibiting a carbon dioxide (CO<jats:sub>2<\/jats:sub>)\u2010switchable volume phase transition is introduced, which displays isothermal swelling\u2010shrinking behavior that is activated by addition and removal of CO<jats:sub>2,<\/jats:sub> respectively. Through systematic compositional studies, shifts in phase transition temperatures of up to 8.6\u00a0\u00b0C are measured upon CO<jats:sub>2<\/jats:sub> exposure, which enables pronounced isothermal swelling in response to CO<jats:sub>2<\/jats:sub>, reaching up to a fivefold increase in mass. The shift in transition temperature and the extent of swelling are controlled by the hydrogel composition, thus enabling the transition temperature and swelling degree to be tuned a priori for a particular application. Controlled release experiments from these gels upon a CO<jats:sub>2<\/jats:sub>\u2010induced phase transition suggest viability for drug delivery applications. It is anticipated that this work will motivate and expand efforts to exploit phase behavior for smart material development.<\/jats:p>","DOI":"10.1002\/marc.202400772","type":"journal-article","created":{"date-parts":[[2024,11,23]],"date-time":"2024-11-23T13:09:05Z","timestamp":1732367345000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Swelling\u2010Shrinking Behavior of a Hydrogel with a CO<sub>2<\/sub>\u2010Switchable Volume Phase Transition Temperature"],"prefix":"10.1002","volume":"46","author":[{"given":"Sarah R.","family":"Sergi","sequence":"first","affiliation":[{"name":"Department of Chemical and Biomolecular Engineering Lafayette College 740 High Street Easton PA 18042 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James J.","family":"Hastie","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biomolecular Engineering Lafayette College 740 High Street Easton PA 18042 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Finlay J. 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