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H&amp;E staining and DNA quantification of B\u2010ECM manifest successful removal of cell nuclei alongside preserved biochemical cues (e.g., glycosaminoglycans, proteins, etc.), which influenced the migration and neurite outgrowth of Schwann cells and Pheochromocytoma (PC12) cells in a dose\u2010dependent manner both in the solubilized form and as aligned fibers in vitro. PCL\/Gel fibers (layer thickness = 400\u2013500 \u00b5m) enhanced the transport of nutrients, while tubular scaffolds suppressed the accumulation of inflammatory cells at the scaffold\u2010tissue interface. In vivo evaluation of aNGCs in a rat sciatic nerve defect model (length = 1 cm) exhibit host cell infiltration aligned along the alignment direction of fibers. Nerve regeneration is higher in aNGCs containing B\u2010ECM. 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