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Rapid Commun."],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>For nanomedical targeting and drug delivery purposes, the noncovalent assembly of polymer building blocks into defined nanostructures is an intense area of research. One of the key assets desirable to know for the potential nanocarrier is the stability under conditions close to those in application scenarios. Here, a series of polymer building blocks based on poly(ethylene glycol) (PEG), which comprise a functional end group facilitating self\u2010assembly into supramolecular polymer bottlebrushes (SPBs), is hydrodynamically studied. The building blocks, and consequently the assemblies, are labeled with a cyanine5 (Cy5) dye enabling selective tracing of the materials in human serum (HS) in analytical ultracentrifugation (AUC) experiments. Our experiments reveal a long\u2010term stability of the noncovalent assemblies over one month of storage of the materials in HS at body temperature. At the same time, the interaction of some of the Cy5 moieties with the transport protein human serum albumin (HSA) is evidenced.<\/jats:p>","DOI":"10.1002\/marc.202400890","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T19:18:16Z","timestamp":1741720696000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Supramolecular Polymer Bottlebrushes: In Situ Assessment of Noncovalent Assemblies in Human Serum by Analytical Ultracentrifugation"],"prefix":"10.1002","volume":"46","author":[{"given":"Ilya","family":"Anufriev","sequence":"first","affiliation":[{"name":"Laboratory of Organic and Macromolecular Chemistry Friedrich Schiller University Jena  Humboldtstr. 10 07743 Jena Germany"},{"name":"Helmholtz Institute for Polymers in Energy Applications Jena (HIPOLE Jena)  Lessingstr. 12\u201314 07743 Jena Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Klein","sequence":"additional","affiliation":[{"name":"Laboratory of Organic and Macromolecular Chemistry Friedrich Schiller University Jena  Humboldtstr. 10 07743 Jena Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Hoeppener","sequence":"additional","affiliation":[{"name":"Laboratory of Organic and Macromolecular Chemistry Friedrich Schiller University Jena  Humboldtstr. 10 07743 Jena Germany"},{"name":"Jena Center for Soft Matter Friedrich Schiller University Jena  Philosophenweg 7 07743 Jena Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes C.","family":"Brendel","sequence":"additional","affiliation":[{"name":"Macromolecular Chemistry I University of Bayreuth  Universit\u00e4tsstr. 30 95447 Bayreuth Germany"},{"name":"Institute of Macromolecular Research (BIMF) and Bavarian Polymer Institute (BPI) University of 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