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Rapid Commun."],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A series of water\u2010soluble, PEG\u2010based single\u2010chain cyclized\/knotted polymers are successfully synthesized through the homopolymerization of poly(ethylene glycol) diacrylate (PEGDA) (<jats:italic>M<\/jats:italic><jats:sub>n<\/jats:sub>\u00a0 = 575 and 700 g mol<jats:sup>\u22121<\/jats:sup>, respectively) via enhanced intramolecular cyclization. The homopolymerization of the diacrylate macromers first proceeds through linear propagation, followed by self\u2010cyclization. Under high monomer\u2010to\u2010initiator ratios (e.g., 100\u2013500) and room temperature, cyclized polymers with high cyclized ratios of up to 70% are achieved without gelation. 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