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These SP\/DOX\u2010SS\u2010PEG NPs exhibit high photothermal stability and significant GSH\u2010triggered DOX release. In vitro studies demonstrate that SP\/DOX\u2010SS\u2010PEG NPs display enhanced cellular uptake and robust cytotoxicity against 4T1 cancer cells under 808 nm laser irradiation. Upon intravenous injection in tumor\u2010bearing mice, NIR\u2010II FI reveals efficient tumor accumulation and prolonged retention of the NPs. In vivo anti\u2010tumor efficacy studies indicate that SP\/DOX\u2010SS\u2010PEG NPs combined with 808 nm laser irradiation achieve the most significant inhibition of tumor growth, with minimal systemic toxicity. Taken together, these findings highlight the promising potential of SP\/DOX\u2010SS\u2010PEG NPs as a multifunctional platform for precision cancer theranostics, integrating efficient NIR\u2010II imaging, GSH\u2010triggered drug release, and dual chemo\u2010photothermal therapy.<\/jats:p>","DOI":"10.1002\/marc.202401098","type":"journal-article","created":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T08:41:01Z","timestamp":1740213661000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["GSH\u2010Responsive Semiconducting Polymer as a Nanotheranostic Platform for NIR\u2010II Imaging\u2010Guided Chemo\u2010Photothermal Therapy"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2103-8118","authenticated-orcid":false,"given":"Ben","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Flexible Electronics (LoFE) Jiangsu Key Laboratory of Smart 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