{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:41:50Z","timestamp":1790797310721,"version":"4.1.0"},"reference-count":66,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T00:00:00Z","timestamp":1743033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T00:00:00Z","timestamp":1743033600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["445804074"],"award-info":[{"award-number":["445804074"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["391977956"],"award-info":[{"award-number":["391977956"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["535904448"],"award-info":[{"award-number":["535904448"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Macromol. Rapid Commun."],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Selectively targeting diseases with therapeutics remains a crucial yet still unsatisfied challenge in (nano)medicine. In recent years, a large body of biologically based drug carrier systems are produced which have proven to be suitable for the efficient transport of active compounds such as biopharmaceuticals and biotechnological drugs. However, those naturally occurring materials often entail risks, for example, due to accessible, functional groups created by uncontrolled protein denaturation processes of enzymes (e.g., proteases) which can lead to unwanted side effects in the body. To deal with this issue, designing bio\u2010inspired synthetic copolymers offers a suitable alternative compared to systems based on materials derived from natural sources. Owing to the variety of electrostatically interacting motifs abundant in nature, synthetic statistical copolymers are developed with different polarity and zwitterionic arginine\u2010derived units. To achieve the required physicochemical demands, a simple one\u2010step synthesis approach is applied, the so\u2010called xanthate\u2010supported photo\u2010iniferter reversible\u2010addition\u2010fragmentation chain\u2010transfer (XPI\u2010RAFT) polymerization. The cellular association of these polymers is compared to a fully non\u2010ionic polymer. The results highlight new findings in the design of zwitterionic macromolecule structures for medical applications and further progress the understanding of the driving forces of the cell specificity of polyzwitterions.<\/jats:p>","DOI":"10.1002\/marc.202401099","type":"journal-article","created":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T02:28:57Z","timestamp":1743301737000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Bio\u2010Inspired, Zwitterionic Copolymers with Amphiphilic Character"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5072-3931","authenticated-orcid":false,"given":"Theresa M.","family":"Lutz","sequence":"first","affiliation":[{"name":"Macromolecular Chemistry University of Bayreuth  Universit\u00e4tsstra\u00dfe 30 95447 Bayreuth Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cevin P.","family":"Braksch","sequence":"additional","affiliation":[{"name":"Institute of Chemistry University of Potsdam  Karl\u2010Liebknecht\u2010Str. 24\u201325 14476 Potsdam Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0248-9943","authenticated-orcid":false,"given":"Jonas","family":"De Breuck","sequence":"additional","affiliation":[{"name":"Macromolecular Chemistry University of Bayreuth  Universit\u00e4tsstra\u00dfe 30 95447 Bayreuth Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5330-7186","authenticated-orcid":false,"given":"Matthias","family":"Hartlieb","sequence":"additional","affiliation":[{"name":"Institute of Chemistry University of Potsdam  Karl\u2010Liebknecht\u2010Str. 24\u201325 14476 Potsdam Germany"},{"name":"Fraunhofer Institue for Applied Polymer Research (IAP)  Geiselbergstra\u00dfe 69 14476 Potsdam Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8525-2324","authenticated-orcid":false,"given":"Meike N.","family":"Leiske","sequence":"additional","affiliation":[{"name":"Macromolecular Chemistry University of Bayreuth  Universit\u00e4tsstra\u00dfe 30 95447 Bayreuth Germany"},{"name":"Bavarian Polymer Institute  Universit\u00e4tsstra\u00dfe 30 95447 Bayreuth Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,27]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201202080"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2016.06.002"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2007.06.008"},{"key":"e_1_2_9_2_3","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-009-0053-z"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2017.04.036"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2012.04.036"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/smll.200801602"},{"key":"e_1_2_9_4_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2011.10.023"},{"key":"e_1_2_9_4_4","doi-asserted-by":"publisher","DOI":"10.1002\/med.20225"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2008.05.010"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2003.08.008"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2022.114622"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.24184"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1409"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578-021-00358-0"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/bm500169p"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c02347"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn901414q"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/03602559.2014.986811"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/macp.202300200"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.4c01061"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201100001"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.2c00216"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.2c00803"},{"key":"e_1_2_9_17_3","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.2c00143"},{"key":"e_1_2_9_17_4","doi-asserted-by":"publisher","DOI":"10.1038\/s41428-023-00774-9"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-020-0375-3"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2023.12.017"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2024.05.006"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2020.102300"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmacrolett.4c00321"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.progpolymsci.2020.101311"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.macromol.7b00767"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1CS00069A"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/9783527821358.ch12"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/marc.202100514"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2SC05197D"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.202400316"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/pol.20230591"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/marc.202100615"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2023.01.005"},{"key":"e_1_2_9_29_3","doi-asserted-by":"publisher","DOI":"10.1002\/marc.202400623"},{"key":"e_1_2_9_29_4","doi-asserted-by":"publisher","DOI":"10.1021\/acs.macromol.2c00633"},{"key":"e_1_2_9_29_5","doi-asserted-by":"publisher","DOI":"10.1021\/acs.macromol.3c02313"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/macp.201600161"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.34853"},{"key":"e_1_2_9_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.35213"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2024.102572"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.14490"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar500147x"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsos.201963"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/pro.2647"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2010.01.007"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2621.1985.tb13433.x"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/acspolymersau.3c00048"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c13987"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.7b12484"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/la2024605"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp983852i"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/bip.21637"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi900649t"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2018.11.117"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.36199"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2020.06.007"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202301761"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/pola.27937"}],"container-title":["Macromolecular Rapid Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/marc.202401099","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/marc.202401099","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/marc.202401099","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T12:20:02Z","timestamp":1786191602000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/marc.202401099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,27]]},"references-count":66,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/marc.202401099"],"URL":"https:\/\/doi.org\/10.1002\/marc.202401099","archive":["Portico"],"relation":{},"ISSN":["1022-1336","1521-3927"],"issn-type":[{"value":"1022-1336","type":"print"},{"value":"1521-3927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,27]]},"assertion":[{"value":"2024-12-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2401099"}}