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Rapid Commun."],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Poly(2\u2010isopropyl\u20102\u2010oxazoline) (\n                    <jats:bold>\n                      P\n                      <jats:italic>i<\/jats:italic>\n                      PrOx\n                    <\/jats:bold>\n                    ) is a biocompatible polymer with a temperature\u2010sensitive behavior that exhibits hydrophilic\u2010hydrophobic phase transition in response to temperature changes via lower critical solution temperature (LCST). Typically, the LCST of\n                    <jats:bold>\n                      P\n                      <jats:italic>i<\/jats:italic>\n                      PrOx\n                    <\/jats:bold>\n                    s changes significantly depending on their molecular weight or concentration. In this study, bottlebrush polymers (\n                    <jats:bold>\n                      P\n                      <jats:italic>i<\/jats:italic>\n                      PrOx\u2010BP\n                    <\/jats:bold>\n                    s) are created using cascade enyne metathesis polymerization of\n                    <jats:bold>\n                      P\n                      <jats:italic>i<\/jats:italic>\n                      PrOx\n                    <\/jats:bold>\n                    \u2010based macromonomer. The unique bottlebrush shape of\n                    <jats:bold>\n                      P\n                      <jats:italic>i<\/jats:italic>\n                      PrOx\u2010BP\n                    <\/jats:bold>\n                    s, with densely packed side chains, makes them more stable and less sensitive to changes in their size or concentration. Unlike traditional linear\n                    <jats:bold>\n                      P\n                      <jats:italic>i<\/jats:italic>\n                      PrOx\n                    <\/jats:bold>\n                    , the\n                    <jats:bold>\n                      P\n                      <jats:italic>i<\/jats:italic>\n                      PrOx\u2010BP\n                    <\/jats:bold>\n                    s showed minimal changes in thermal transition temperatures, even with large changes in their molecular weight or concentration. The measurements showed that\n                    <jats:bold>\n                      P\n                      <jats:italic>i<\/jats:italic>\n                      PrOx\u2010BP\n                    <\/jats:bold>\n                    s undergo sharp and consistent changes in behavior, making them more reliable for applications like sensors, drug delivery, and other systems that need precise temperature control. This research offers valuable insights into how the design of polymers can improve their performance in various practical uses.\n                  <\/jats:p>","DOI":"10.1002\/marc.202500021","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T16:51:24Z","timestamp":1741711884000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Thermo\u2010Responsive Poly(2\u2010isopropyl\u20102\u2010oxazoline)\u2010Based Bottlebrush Polymers via Cascade Enyne Metathesis Polymerization"],"prefix":"10.1002","volume":"46","author":[{"given":"Jaye","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Chemistry Yonsei University  50 Yonsei\u2010ro Seodaemun\u2010gu Seoul 03722 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonwoo","family":"Koo","sequence":"additional","affiliation":[{"name":"Department of Chemistry Chungbuk National University  1 Chungdae\u2010ro, Seowon\u2010gu Cheongju 28644 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4771-8656","authenticated-orcid":false,"given":"Cheoljae","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Chemistry Chungbuk National University  1 Chungdae\u2010ro, Seowon\u2010gu Cheongju 28644 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1281-6037","authenticated-orcid":false,"given":"Woo\u2010Dong","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Chemistry Yonsei University  50 Yonsei\u2010ro Seodaemun\u2010gu Seoul 03722 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,3]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/pol.20210433"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201309758"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202007274"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1054-8807(02)00165-5"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-3659(90)90138-J"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2008.02.023"},{"key":"e_1_2_8_7_1","first-page":"385","volume":"46","author":"Gen\u00e7 S. 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