{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:49:55Z","timestamp":1791082195495,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2025,3,22]],"date-time":"2025-03-22T00:00:00Z","timestamp":1742601600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["CEX2023\u2010001286\u2010S"],"award-info":[{"award-number":["CEX2023\u2010001286\u2010S"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010067","name":"Gobierno de Arag\u00f3n","doi-asserted-by":"publisher","award":["LMP93_21"],"award-info":[{"award-number":["LMP93_21"]}],"id":[{"id":"10.13039\/501100010067","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010067","name":"Gobierno de Arag\u00f3n","doi-asserted-by":"publisher","award":["E47_23R"],"award-info":[{"award-number":["E47_23R"]}],"id":[{"id":"10.13039\/501100010067","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PDI2021\u20101261132NB\u2010100"],"award-info":[{"award-number":["PDI2021\u20101261132NB\u2010100"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PID2021\u2010127847OB\u2010I00"],"award-info":[{"award-number":["PID2021\u2010127847OB\u2010I00"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Macromol. Rapid Commun."],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In this work, amphiphilic block copolymers (BCs) consisting of a hydrophilic poly(ethylene glycol) methyl ether (PEG) and a degradable polycarbonate block derived from 2,2\u2010bis(hydroxymethyl)propionic acid (bis\u2010MPA) with pendant ureido units, along with corresponding homopolycarbonates are described. Polymers are synthesized by combining ring opening polymerization (ROP) and thiol\u2010ene\/yne functionalization to incorporate UCST\u2010promoting ureido groups. For homopolycarbonates, increasing the ureido groups density along the polymer chain facilitates the upper critical solution temperature (UCST)\u2010type thermoresponse in water. Because of their amphiphilic character, BCs form stable self\u2010assemblies either by direct dispersion in water, co\u2010solvent method or microfluidics. Upon heating, these self\u2010assemblies swell, and collapse due to extensive hydration of the polycarbonate block, rather than becoming solubilized. Thermoresponsiveness is analyzed in terms of the number of ureido groups in the polycarbonate for a given polycarbonate block length as well as the length of polycarbonate block. As a proof of concept, the potential of these self\u2010assemblies as thermoresponsive drug nanocarriers is evaluated, using curcumin as a hydrophobic model drug.<\/jats:p>","DOI":"10.1002\/marc.202500029","type":"journal-article","created":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T11:11:00Z","timestamp":1742728260000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Degradable Ureido\u2010Polycarbonate Block Copolymers with a Complex UCST Thermoresponse"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4833-5796","authenticated-orcid":false,"given":"Javier","family":"Martin\u2010Martin","sequence":"first","affiliation":[{"name":"Instituto de Nanociencia y Materiales de Arag\u00f3n (INMA) CSIC\u2010Universidad de Zaragoza  Zaragoza 50009 Spain"},{"name":"Departamento de Qu\u00edmica Org\u00e1nica Facultad de Ciencias Universidad de Zaragoza  Pedro Cerbuna, 12 Zaragoza 50009 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8677-3316","authenticated-orcid":false,"given":"Miriam","family":"Abad","sequence":"additional","affiliation":[{"name":"Instituto de Nanociencia y Materiales de Arag\u00f3n (INMA) CSIC\u2010Universidad de Zaragoza  Zaragoza 50009 Spain"},{"name":"Departamento de Qu\u00edmica Org\u00e1nica Facultad de Ciencias Universidad de Zaragoza  Pedro Cerbuna, 12 Zaragoza 50009 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0758-1712","authenticated-orcid":false,"given":"Xabier","family":"Lopez de Pariza","sequence":"additional","affiliation":[{"name":"POLYMAT and Department of Polymers and Advanced Materials: Physics Chemistry and Technology Faculty of Chemistry University of the Basque Country UPV\/EHU  Donostia\u2010San Sebasti\u00e1n 20018 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9966-519X","authenticated-orcid":false,"given":"Tiberio A.","family":"Ezquerra","sequence":"additional","affiliation":[{"name":"Instituto de Estructura de la Materia IEM\u2010CSIC  C\/Serrano, 121 Madrid 28006 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2494-3551","authenticated-orcid":false,"given":"Aurora","family":"Nogales","sequence":"additional","affiliation":[{"name":"Instituto de Estructura de la Materia IEM\u2010CSIC  C\/Serrano, 121 Madrid 28006 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6268-0916","authenticated-orcid":false,"given":"Haritz","family":"Sardon","sequence":"additional","affiliation":[{"name":"POLYMAT and Department of Polymers and Advanced Materials: Physics Chemistry and Technology Faculty of Chemistry University of the Basque Country UPV\/EHU  Donostia\u2010San Sebasti\u00e1n 20018 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6873-5244","authenticated-orcid":false,"given":"V\u00edctor","family":"Sebasti\u00e1n","sequence":"additional","affiliation":[{"name":"Instituto de Nanociencia y Materiales de Arag\u00f3n (INMA) CSIC\u2010Universidad de Zaragoza  Zaragoza 50009 Spain"},{"name":"Department of Chemical Engineering and Environmental Technologies University of Zaragoza  Zaragoza 50018 Spain"},{"name":"Networking Research Center on Bioengineering Biomaterials and Nanomedicine (CIBER\u2010BBN)  Madrid 28029 Spain"},{"name":"Laboratorio de Microscop\u00edas Avanzadas Universidad de Zaragoza  Zaragoza 50018 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0922-5615","authenticated-orcid":false,"given":"Luis","family":"Oriol","sequence":"additional","affiliation":[{"name":"Instituto de Nanociencia y Materiales de Arag\u00f3n (INMA) CSIC\u2010Universidad de Zaragoza  Zaragoza 50009 Spain"},{"name":"Departamento de Qu\u00edmica Org\u00e1nica Facultad de Ciencias Universidad de Zaragoza  Pedro Cerbuna, 12 Zaragoza 50009 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5556-2172","authenticated-orcid":false,"given":"Milagros","family":"Pi\u00f1ol","sequence":"additional","affiliation":[{"name":"Instituto de Nanociencia y Materiales de Arag\u00f3n (INMA) CSIC\u2010Universidad de Zaragoza  Zaragoza 50009 Spain"},{"name":"Departamento de Qu\u00edmica Org\u00e1nica Facultad de Ciencias Universidad de Zaragoza  Pedro Cerbuna, 12 Zaragoza 50009 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,22]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.progpolymsci.2019.01.001"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/marc.201200433"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.macromol.3c01920"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3PY00421J"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c22267"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/marc.202000058"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.8b01152"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201802420"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.9b00321"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.9b00963"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.macromol.2c00379"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1SC05022B"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8PY00960K"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.macromol.8b01810"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.5b02006"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym13244424"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemmater.7b02748"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-30220-y"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0PY00865F"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b02723"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6BM00584E"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.0c00883"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201900224"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.macromol.0c02880"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1039\/C2PY20718D"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/ma102882v"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0927-7765(99)00058-2"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3py00576c"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym13050684"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/pol.20210430"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.progpolymsci.2007.05.009"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/marc.202400286"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S108812"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c01117"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.202100528"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.1c01520"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/pola.28183"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/macp.201400546"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5SM00499C"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.macromol.5b02543"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3py01648j"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.macromol.9b01327"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.macromol.5b00149"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.macromol.3c00534"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2005.05.009"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp700113r"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2023.104326"}],"container-title":["Macromolecular Rapid Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/marc.202500029","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T01:35:42Z","timestamp":1763170542000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/marc.202500029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,22]]},"references-count":47,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/marc.202500029"],"URL":"https:\/\/doi.org\/10.1002\/marc.202500029","archive":["Portico"],"relation":{},"ISSN":["1022-1336","1521-3927"],"issn-type":[{"value":"1022-1336","type":"print"},{"value":"1521-3927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,22]]},"assertion":[{"value":"2025-01-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2500029"}}