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Rapid Commun."],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This study reports the development of elastomeric mesoporous polyurethane (PU) membranes for bioartificial pancreas applications in type 1 diabetes treatment. The membranes are designed to exhibit semi\u2010permeable properties, enabling insulin diffusion while restricting larger immune molecules, such as immunoglobulin G (IgG). Although electrospinning is a widely used technique for fabricating porous membranes for controlled drug release, it typically results in an average pore size on the order of few micrometers, which is two orders of magnitude larger than the mesoporous scale required. In this work, a green\u2010electrospinning process using waterborne PU suspension and poly(ethylene oxide) (PEO) is employed, followed by thermal annealing and washing steps. The resulting membranes exhibit a controlled pore size in the mesoporous range (\u224820\u00a0nm measured by capillary flow porometry). Diffusion tests confirmed selective permeability, with a recovery rate of 25% for insulin and a recovery rate below 5% for IgG, meeting therapeutic needs. In vivo characterizations show no degradation and good biocompatibility of the membranes without chronic inflammation. Moreover, mechanical characterization demonstrates the membranes' flexibility and strength, making them suitable for minimally invasive surgical implantation. These findings underscore the potential of PU membranes for long\u2010term biomedical applications, addressing critical challenges in permeability and mechanical stability.<\/jats:p>","DOI":"10.1002\/marc.202500049","type":"journal-article","created":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T08:14:26Z","timestamp":1739520866000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Mesoporous Semi\u2010Permeable Flexible Polyurethane Membranes: Advancing Bioartificial Pancreas Design for Type 1 Diabetes Treatment"],"prefix":"10.1002","volume":"46","author":[{"given":"Bryan","family":"Gross","sequence":"first","affiliation":[{"name":"Institut de Chimie et Proc\u00e9d\u00e9s pour l'Energie, l'Environnement et la Sant\u00e9, ICPEES UMR 7515, CNRS Universit\u00e9 de Strasbourg, Ecole Europ\u00e9enne de Chimie, Polym\u00e8res et Mat\u00e9riaux  25 rue Becquerel Strasbourg Cedex 267087 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7587-4939","authenticated-orcid":false,"given":"Emeline","family":"Lobry","sequence":"additional","affiliation":[{"name":"Institut de Chimie et Proc\u00e9d\u00e9s pour l'Energie, l'Environnement et la Sant\u00e9, ICPEES UMR 7515, CNRS Universit\u00e9 de Strasbourg, Ecole Europ\u00e9enne de Chimie, Polym\u00e8res et Mat\u00e9riaux  25 rue Becquerel Strasbourg Cedex 267087 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5766-2596","authenticated-orcid":false,"given":"S\u00e9verine","family":"Sigrist","sequence":"additional","affiliation":[{"name":"Defymed, 9 rue Albert Calmette  Strasbourg 67200 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7134-7499","authenticated-orcid":false,"given":"Elisa","family":"Maillard","sequence":"additional","affiliation":[{"name":"Defymed, 9 rue Albert Calmette  Strasbourg 67200 France"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, UMR_S 1121 Universit\u00e9 de Strasbourg, Facult\u00e9 de Chirurgie Dentaire  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9602-1735","authenticated-orcid":false,"given":"Jordan","family":"Magisson","sequence":"additional","affiliation":[{"name":"Defymed, 9 rue Albert Calmette  Strasbourg 67200 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles\u2010Thibault","family":"Burcez","sequence":"additional","affiliation":[{"name":"Defymed, 9 rue Albert Calmette  Strasbourg 67200 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Pires","sequence":"additional","affiliation":[{"name":"Defymed, 9 rue Albert Calmette  Strasbourg 67200 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6018-1523","authenticated-orcid":false,"given":"Anne","family":"H\u00e9braud","sequence":"additional","affiliation":[{"name":"Institut de Chimie et Proc\u00e9d\u00e9s pour l'Energie, l'Environnement et la Sant\u00e9, ICPEES UMR 7515, CNRS Universit\u00e9 de Strasbourg, Ecole Europ\u00e9enne de Chimie, Polym\u00e8res et Mat\u00e9riaux  25 rue Becquerel Strasbourg Cedex 267087 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3037-4129","authenticated-orcid":false,"given":"Guy","family":"Schlatter","sequence":"additional","affiliation":[{"name":"Institut de Chimie et Proc\u00e9d\u00e9s pour l'Energie, l'Environnement et la Sant\u00e9, ICPEES UMR 7515, CNRS Universit\u00e9 de Strasbourg, Ecole Europ\u00e9enne de Chimie, Polym\u00e8res et Mat\u00e9riaux  25 rue Becquerel Strasbourg Cedex 267087 France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,14]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-S062"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eng.2021.10.021"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-022-04369-0"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202100820"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.49.2.157"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i37.13512"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.01.055"},{"key":"e_1_2_8_8_1","unstructured":"Z.Liu Cellular Endocrinology in Health and Disease 2nd ed. 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