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Rapid Commun."],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Polyacetals represent a novel category of degradable polymers, exhibiting remarkable potential for utilization in biomedical and pharmaceutical applications due to their controllable degradation behavior under physiological conditions. The organocatalyst 1,5,7\u2010triazabicyclo[4.4.0]dec\u20105\u2010ene (TBD) was used for the ring\u2010opening polymerization (ROP) of 2\u2010methyl\u20101,3\u2010dioxane\u20104\u2010one. Whereas standard reaction conditions, suitable for lactide polymerization resulted in a polyester due to loss of acetaldehyde, the amount of esteracetal repeating units could be tailored by the polymerization conditions. Performing the ROP at \u221235\u00b0C at a monomer concentration of 15\u00a0mol\u00a0L<jats:sup>\u22121<\/jats:sup> maximized the incorporation of labile acetal groups to 50 mol%. The versatility of this polymerization system was demonstrated through the successful initiation with a wide range of alcohols, including 1\u2010pyrenemethanol for end\u2010group analysis via size exclusion chromatography with UV detection and matrix\u2010assisted laser desorption\u2010ionization mass spectrometry, as well as various macroinitiators such as mono\u2010 and bifunctional poly(ethylene glycol)s, poly(2\u2010ethyl\u20102\u2010oxazoline), poly(2\u2010<jats:italic>n<\/jats:italic>\u2010nonyl\u20102\u2010oxazoline), and poly(2\u2010<jats:italic>iso<\/jats:italic>\u2010propyl\u20102\u2010oxazoline), thereby facilitating the synthesis of well\u2010defined block copolymers.<\/jats:p>","DOI":"10.1002\/marc.202500273","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T14:16:24Z","timestamp":1751897784000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Polyesteracetals via TBD 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