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The high reactivity and acid\u2010responsive properties of HPM enable in situ, rapid liposome encapsulation, significantly enhancing liposome stability while ensuring excellent injectability and localized therapeutic effects. As a proof of concept, this hydrogel system is applied as a skin dressing, facilitating controlled liposome release while improving stratum corneum hydration, thereby markedly enhancing the transdermal delivery of the antioxidant coenzyme Q10 (CoQ10). Compared to the direct application of free CoQ10 dispersions, this system achieves an impressive 16.6\u2010fold increase in bioavailability, highlighting its strong potential for applications in transdermal drug delivery and localized disease treatment.<\/jats:p>","DOI":"10.1002\/marc.202500310","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T08:21:54Z","timestamp":1748334114000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Hyperbranched Macromonomer\u2010Based Gelation of Hyaluronic Acid for Efficient Liposome Encapsulation and Improved Transdermal Delivery"],"prefix":"10.1002","volume":"46","author":[{"given":"Lingxi","family":"Guo","sequence":"first","affiliation":[{"name":"State Key Laboratory of Materials\u2010Oriented Chemical Engineering College of Chemical Engineering Nanjing Tech University  30 Puzhu South Road Nanjing 211816 P. R. 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