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Both in vitro and in vivo experiments demonstrated that PEGylated CAT (CAT\u2010PEG) efficiently reduced reactive oxygen species (ROS) levels, mitigated oxidative stress, and improved liver function post\u2010reperfusion. These findings suggest that CAT\u2010PEG is a promising therapeutic strategy for treating IRI, with potential for broader applications in liver transplantation and other conditions involving oxidative damage.<\/jats:p>","DOI":"10.1002\/marc.202500367","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T13:34:17Z","timestamp":1748266457000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Poly(Ethylene Glycol)\u2010Modified Catalase Blocking Reactive Oxygen Species for the Treatment of Hepatic Ischemia"],"prefix":"10.1002","volume":"46","author":[{"given":"Sai","family":"Gao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Organic\u2010Inorganic Composites Beijing Advanced Innovation Center for Soft Matter Science and Engineering College of Life Science and Technology Beijing University of Chemical Technology  Beijing 100029 P. R. 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