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The Leuchs synthesis was modified and optimized for the preparation of high\u2010purity\n                    <jats:italic>N<\/jats:italic>\n                    \u2010ethylglycine NCA monomers, enabling controlled polymerization with the use of organic acid catalysts. The resulting p\n                    <jats:italic>N<\/jats:italic>\n                    EtGly have low polydispersity values (\u00d0 &lt; 1.05) and quantitative end\u2010group fidelity, enabling the synthesis of well\u2010defined polymer\u2013lipid and polymer\u2013protein conjugates. A palmitamide\u2010functionalized p\n                    <jats:italic>N<\/jats:italic>\n                    EtGly demonstrated near\u2010quantitative conversion to polymer\u2013lipid conjugates. Furthermore, maleimide\u2010functionalized p\n                    <jats:italic>N<\/jats:italic>\n                    EtGly was conjugated to human serum albumin (HSA) via thiol\u2013maleimide coupling, forming a protein\u2013polymer conjugate with high purity. These results establish p\n                    <jats:italic>N<\/jats:italic>\n                    EtGly as another interesting hydrophilic polymer for biomedical applications, particularly in lipid\u2010based drug delivery and bioconjugation strategies.\n                  <\/jats:p>","DOI":"10.1002\/marc.202500422","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T03:48:33Z","timestamp":1752724113000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Synthesis of Heterotelechelic Poly(\n                    <i>N<\/i>\n                    \u2010ethylglycine) Polymers: from Polypeptoid Lipid Conjugates to Protein\u2010Polymer Conjugates"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8197-0581","authenticated-orcid":false,"given":"Ewout","family":"Buijs","sequence":"first","affiliation":[{"name":"Leiden Academic Centre for Drug Research (LACDR) Leiden University  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4091-3595","authenticated-orcid":false,"given":"Zlata","family":"Nagorna","sequence":"additional","affiliation":[{"name":"Leiden Academic Centre for Drug Research (LACDR) Leiden University  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5725-6531","authenticated-orcid":false,"given":"Joachim F. 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